Bone Marrow Avatars: Mimicking Hematopoiesis in a Dish
- PMID: 36744319
- DOI: 10.1158/2159-8290.CD-22-1303
Bone Marrow Avatars: Mimicking Hematopoiesis in a Dish
Abstract
Faithful recapitulation of human bone marrow complexity has been a major challenge for the sci-entific community for many years. In this issue of Cancer Discovery, Khan and colleagues present an improved induced pluripotent stem cell differentiation protocol that generates bone marrow organoids re-creating key characteristics of human marrow. See related article by Khan et al., p. 364 (8).
©2023 American Association for Cancer Research.
Comment on
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Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.Cancer Discov. 2023 Feb 6;13(2):364-385. doi: 10.1158/2159-8290.CD-22-0199. Cancer Discov. 2023. PMID: 36351055 Free PMC article.
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