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Editorial
. 2023 Feb 6;13(2):260-262.
doi: 10.1158/2159-8290.CD-22-1304.

A Splendid New Beginning at the End of a 40-Year Quest: The First KRASG12D Inhibitor in Pancreatic Cancer

Alexandra Redding  1 , Elda Grabocka  1
Affiliations
Editorial

A Splendid New Beginning at the End of a 40-Year Quest: The First KRASG12D Inhibitor in Pancreatic Cancer

Alexandra Redding et al. Cancer Discov. .

Abstract

The first KRASG12D inhibitor, MRTX113, leads to regression in multiple mouse models of PDAC as a monotherapy. MRTX113 blocks cancer cell proliferation, induces cancer cell death, and promotes immune infiltration and activation. See related article by Kemp et al., p. 298 (6).

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