Imaging gas-exchange lung function and brain tissue uptake of hyperpolarized 129 Xe using sampling density-weighted MRSI

Abstract

Purpose: Imaging of the different resonances of hyperpolarized ¹²⁹ Xe in the brain and lungs was performed using a 3D sampling density-weighted MRSI technique in healthy volunteers.

Methods: Four volunteers underwent dissolved-phase hyperpolarized ¹²⁹ Xe imaging in the lung with the MRSI technique, which was designed to improve the point-spread function while preserving SNR (1799 phase-encoding steps, 14-s breath hold, 2.1-cm isotropic resolution). A frequency-tailored RF excitation pulse was implemented to reliably excite both the ¹²⁹ Xe gas and dissolved phase (tissue/blood signal) with 0.1° and 10° flip angles, respectively. Images of xenon gas in the lung airspaces and xenon dissolved in lung tissue/blood were used to generate quantitative signal ratio maps. The method was also optimized and used for imaging dissolved resonances of ¹²⁹ Xe in the brain in 2 additional volunteers.

Results: High-quality regional spectra of hyperpolarized ¹²⁹ Xe were achieved in both the lung and the brain. Ratio maps of the different xenon resonances were obtained in the lung with sufficient SNR (> 10) at both 1.5 T and 3 T, making a triple Lorentzian fit possible and enabling the measurement of relaxation times and xenon frequency shifts on a voxel-wise basis. The imaging technique was successfully adapted for brain imaging, resulting in the first demonstration of 3D xenon brain images with a 2-cm isotropic resolution.

Conclusion: Density-weighted MRSI is an SNR and encoding-efficient way to image ¹²⁹ Xe resonances in the lung and the brain, providing a valuable tool to quantify regional spectroscopic information.

Keywords: brain; hyperpolarized 129Xe; lung; spectroscopic imaging.