Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 1;35(1):127-129.
doi: 10.1097/ANA.0000000000000879. Epub 2022 Dec 6.

Perinatal Anesthesia Exposure and Autism Spectrum Disorders

Affiliations
Review

Perinatal Anesthesia Exposure and Autism Spectrum Disorders

Philipp Houck et al. J Neurosurg Anesthesiol. .

Abstract

Epidural analgesia is frequently used during labor among pregnant people in the United States. Different factors have been associated with the development of autism spectrum disorder in the epidemiological literature: maternal health, infectious and pharmacological etiologies, social factors, and environmental exposures. Current data indicates no clear association between the use of epidural labor analgesia and the development of autism spectrum disorder in the offspring. This review presents the public health perspective on the postulated association between perinatal anesthesia exposure and autism spectrum disorders.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. National Center on Birth Defects and Developmental Disabilities, Center for Disease Control and Prevention. Available at: https://www.cdc.gov/ncbddd/autism/addm.html . Accessed 31 May 2022.
    1. Zimmerman AW, Connors SL. Could autism be treated prenatally? Science. 2014;343:675–679. doi:10.1126/science.1250214 - DOI
    1. Ozonoff S, Young GS, Carter A, et al. Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics. 2011;128:e488–e495. doi:10.1542/peds.2010-2825 - DOI
    1. Muhle RA, Reed HE, Stragios KA, et al. The emerging clinical neuroscience of autism spectrum disorder: A review. Jama Psychiatry. 2018;75:514–523. doi:10.1001/jamapsychiatry.2017.4685 - DOI
    1. Roman-Urrestarazu A, van Kessel R, Allison C, et al. Association of race/ethnicity and social disadvantage with autism prevalence in 7 million school children in england. JAMA Pediatr. 2021;175:e210054. doi:10.1001/jamapediatrics.2021.0054 - DOI