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. 2023 Apr;201(2):302-307.
doi: 10.1111/bjh.18681. Epub 2023 Feb 6.

A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia

Yu-Hung Wang  1   2   3 , Chi-Yuan Yao  2   4 , Chien-Chin Lin  2   4 , Kristian Gurashi  1 , Fabio M R Amaral  3 , Hasse Bossenbroek  1 , Andres Jerez  5 , Tim C P Somervaille  3 , Moritz Binder  6 , Mrinal M Patnaik  6 , Hsin-An Hou  2 , Wen-Chien Chou  2   4 , Kiran Batta  1 , Daniel H Wiseman  1 , Hwei-Fang Tien  2   7
Affiliations

A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia

Yu-Hung Wang et al. Br J Haematol. 2023 Apr.

Abstract

Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17-gene LSC score, LSC-17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three-gene expression signature (LSC-3, derived from the LSC-17 score) as an independent and robust prognostic factor for leukaemia-free and overall survival in CMML. We propose that LSC-3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.

Keywords: chronic myelomonocytic leukaemia; leukaemia stem cell; prognostic scoring system.

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References

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