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. 2023 Mar;77(2):403-411.
doi: 10.1007/s11418-023-01681-2. Epub 2023 Feb 7.

Eumitrins I-K: three new xanthone dimers from the lichen Usnea baileyi

Van-Kieu Nguyen  1   2 , Phan-Si-Nguyen Dong  3   4 , Hoai-Vu Nguyen-Si  3   4 , Ek Sangvichien  5 , Thanh-Nha Tran  6 , Le-Thuy-Thuy-Trang Hoang  6 , Minh-Trung Dao  6 , Hai-Nguyen  3   4 , Hoang-Vinh-Truong Phan  3   4 , Hioki Yusuke  7 , Tohru Mitsunaga  8 , Warinthorn Chavasiri  9
Affiliations

Eumitrins I-K: three new xanthone dimers from the lichen Usnea baileyi

Van-Kieu Nguyen et al. J Nat Med. 2023 Mar.

Abstract

In the continuing discovery and structure elucidation of natural xanthone dimers, which are still rarely reported in absolute configuration, three new xanthone dimers, eumitrins I-K (1-3) were isolated from the lichen Usnea baileyi, a rich source of natural xanthone dimers. Their structures were elucidated unambiguously by spectroscopic analyses, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance spectroscopy (1D and 2D NMR). The absolute configuration of all three compounds was established through DP4 probability and ECD calculation. All compounds revealed weak activity for their enzymatic inhibition against α-glucosidase and tyrosinase, as well as antibacterial activity.

Keywords: Antibacterial; Dimeric xanthone; Enzyme inhibitory; Lichen; Usnea baileyi; α-Glucosidase.

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