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[Preprint]. 2023 Jan 23:rs.3.rs-2443973.
doi: 10.21203/rs.3.rs-2443973/v1.

Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United States

Abubaker Ibrahim Elbur  1 , Musie Ghebremichael  2 , Deborah Konkle-Parker  3 , Deborah L Jones  4 , Shelby Collins  5 , Adaora A Adimora  6 , Michael F Schneider  7 , Mardge H Cohen  8 , Bani Tamraz  9 , Michael Plankey  10 , Tracey Wilson  11 , Adebola Adedimeji  12 , Jessica E Haberer  1 , Denise L Jacobson  13
Affiliations

Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United States

Abubaker Ibrahim Elbur et al. Res Sq. .

Update in

Abstract

Background Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy. Methods We included women with HIV (aged ≥ 18) enrolled in the Women's Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy. Results Overall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group. Conclusions The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence.

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Conflict of interest statement

Competing interests:

No conflicts of interest to declare.

Figures

Figure 1
Figure 1
a. Trends of >95% self-report adherence to ART over the study period. b. Trends of polypharmacy (5+ medications) over the study period
Figure 2
Figure 2
Adherence trajectories
Figure 3
Figure 3
Trajectories of polypharmacy (considering all medications)
See this image and copyright information in PMC

References

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