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Review
. 2023 Jan 31:16:381-389.
doi: 10.2147/JIR.S385977. eCollection 2023.

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Lujian Zhu #  1 , Shengnan Luo #  1 , Yin Zhu  2 , Shiyue Tang  1 , Chenge Li  3 , Xiaozhi Jin  4 , Faling Wu  4 , Huimian Jiang  4 , Lina Wu  4 , Yejin Xu  1
Affiliations
Review

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Lujian Zhu et al. J Inflamm Res. .

Abstract

Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy.

Keywords: cell death; ferroptosis; iron metabolism; liver disease; oxidative stress.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Schematic illustration of the main mechanisms of ferroptosis.
Figure 2
Figure 2
Ferroptosis in chronic liver diseases.
See this image and copyright information in PMC

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