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Meta-Analysis
. 2023 Jul;162(1):39-50.
doi: 10.1002/ijgo.14714. Epub 2023 Feb 24.

Interventions to increase uptake of influenza vaccination in pregnancy: A systematic review and meta-analysis

Eleonora Brillo  1   2 , Valentina Tosto  1 , Ersilia Buonomo  2
Affiliations
Meta-Analysis

Interventions to increase uptake of influenza vaccination in pregnancy: A systematic review and meta-analysis

Eleonora Brillo et al. Int J Gynaecol Obstet. 2023 Jul.

Abstract

Background: Maternal influenza vaccination has been introduced in several countries to prevent influenza-related morbidity and mortality in pregnant women, fetuses, and infants too young to be vaccinated.

Objectives: To analyze the available randomized controlled trials (RCTs) on the effectiveness of pregnant women-focused interventions to increase influenza vaccination uptake during pregnancy.

Search strategy: Medline, CINAHL, Scopus, Web of Science, and Cochrane Trial were searched on August 25, 2021.

Selection criteria: RCTs assessing the effectiveness of pregnant women-focused interventions in increasing influenza vaccination among pregnant women were included.

Data collection and analysis: Two independent reviewers extracted data. A random-effects meta-analysis was conducted to estimate pooled odds ratios (ORs).

Main results: Seven RCTs were selected. Overall, the interventions had a significant effect in increasing influenza vaccination during pregnancy compared with standard care (OR 1.78, 95% confidence interval [CI] 1.25-2.54; P = 0.001; I2 = 67%). However, subgroup analysis suggested that influenza vaccination uptake only was associated with educational interventions (OR 2.71, 95% CI 1.93-3.81; P < 0.001; I2 = 0%).

Conclusions: We found that several educational interventions for pregnant women can effectively increase influenza vaccination uptake in this population. Specifically, pamphlets, websites, and brief one-to-one education can be effective tools.

Registration: CRD42021269478.

Keywords: flu; immunization; influenza vaccine; interventions; maternal vaccination; pregnancy; strategies; vaccine hesitancy.

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References

REFERENCES

    1. Cox S, Posner SF, McPheeters M, et al. Hospitalizations with respiratory illness among pregnant women during influenza season. Obstet Gynecol. 2006;107(6):1315-1322.
    1. Callaghan WM, Chu SY, Jamieson DJ. Deaths from seasonal influenza among pregnant women in the United States, 1998-2005. Obstet Gynecol. 2010;115(5):919-923.
    1. Callaghan WM, Creanga AA, Jamieson DJ. Pregnancy-related mortality resulting from influenza in the United States during the 2009-2010 pandemic. Obstet Gynecol. 2015;126(3):486-490.
    1. Gaunt G, Ramin K. Immunological tolerance of the human fetus. Am J Perinatol. 2001;18(6):299-312.
    1. Bender JM, Ampofo K, Gesteland P, et al. Influenza virus infection in infants less than three months of age. Pediatr Infect Dis J. 2010;29(1):6-9.

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