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Multicenter Study
. 2023 Mar;12(3):e220049.
doi: 10.57264/cer-2022-0049. Epub 2023 Feb 7.

Non-embolic outcomes in patients with cardiovascular disease and atrial fibrillation treated with rivaroxaban

Francisco Marín  1 , Marcelo Sanmartín Fernández  2 , Gonzalo Barón-Esquivias  3   4 , Vivencio Barrios  5 , Iñaki Lekuona  6 , Alejandro I Pérez-Cabeza  7 , Jaime Masjuan  8 , Esther Recalde Del Vigo  9 , José Manuel Vázquez Rodríguez  10 , Roman Freixa-Pamias  11 , Vanessa Roldán Schilling  12 , Fernando Arribas  13   14 , Carles Rafols Priu  15 , Manuel Anguita Sánchez  16
Affiliations
Multicenter Study

Non-embolic outcomes in patients with cardiovascular disease and atrial fibrillation treated with rivaroxaban

Francisco Marín et al. J Comp Eff Res. 2023 Mar.

Abstract

Aim: It is not well known how comorbidities may change the prognosis of atrial fibrillation (AF) patients. This study was aimed to analyze the impact of cardiovascular disease on this population. Materials & methods: EMIR was a multicenter, prospective study, including 1433 AF patients taking rivaroxaban for ≥6 months. Data were analyzed according to the presence of vascular disease. Results: Coronary artery disease was detected in 16.4%, peripheral artery disease/aortic plaque in 6.7%, vascular disease in 28.3%. Patients with coronary artery disease had higher rates (per 100 patient-years) of major adverse cardiovascular events (2.98 vs 0.71; p < 0.001) and cardiovascular death (1.79 vs 0.41; p = 0.004). Those with vascular disease had higher rates of thromboembolic events (1.47 vs 0.44; p = 0.007), major adverse cardiovascular events (2.03 vs 0.70; p = 0.004), and cardiovascular death (1.24 vs 0.39; p = 0.025). Patients with peripheral artery disease/aortic plaque had similar rates. Conclusion: AF patients with vascular disease have a higher risk of non-embolic outcomes.

Keywords: EMIR; MACE; atrial fibrillation; bleeding; coronary artery disease; myocardial infarction; peripheral artery disease; rivaroxaban; stroke; vascular disease.

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Conflict of interest statement

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Figures

Figure 1.
Figure 1.. Flow chart of the study population.
Vascular disease: previous CAD and/or previous cerebrovascular disease and/or PAD. CAD: Coronary artery disease; PAD: Peripheral artery disease.
See this image and copyright information in PMC

References

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