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. 2023 Mar;36(2):135-171.
doi: 10.1007/s10548-023-00941-4. Epub 2023 Feb 7.

Electrophysiological Changes in Patients with Post-stroke Aphasia: A Systematic Review

Sophie Arheix-Parras  1   2   3 , Bertrand Glize  4   5   6 , Dominique Guehl  7   8 , Grégoire Python  9   10
Affiliations

Electrophysiological Changes in Patients with Post-stroke Aphasia: A Systematic Review

Sophie Arheix-Parras et al. Brain Topogr. 2023 Mar.

Abstract

Background Magnetoencephalography (MEG) and electroencephalography (EEG) record two main types of data: continuous measurements at rest or during sleep, and event-related potentials/evoked magnetic fields (ERPs/EMFs) that involve specific and repetitive tasks. In this systematic review, we summarized longitudinal studies on recovery from post-stroke aphasia that used continuous or event-related temporal imaging (EEG or MEG). Methods We searched PubMed and Scopus for English articles published from 1950 to May 31, 2022. Results 34 studies were included in this review: 11 were non-interventional studies and 23 were clinical trials that used specific rehabilitation methods, neuromodulation, or drugs. The results of the non-interventional studies suggested that poor language recovery was associated with slow-wave activity persisting over time. The results of some clinical trials indicated that behavioral improvements were correlated with significant modulation of the N400 component. Discussion Compared with continuous EEG, ERP/EMF may more reliably identify biomarkers of therapy-induced effects. Electrophysiology should be used more often to explore language processes that are impaired after a stroke, as it may highlight treatment challenges for patients with post-stroke aphasia.

Keywords: Aphasia; Electroencephalography; Event-related potential; Evoked magnetic field; Magnetoencephalography; Stroke.

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References

    1. Aerts A, Batens K, Santens P, Van Mierlo P, Huysman E, Hartsuiker R, Hemelsoet D, Duyck W, Raedt R, Van Roost D, De Letter M (2015) Aphasia therapy early after stroke: behavioural and neurophysiological changes in the acute and post-acute phases. Aphasiology 29(7):845–871. https://doi.org/10.1080/02687038.2014.996520 - DOI
    1. Aerts A, van Mierlo P, Hartsuiker RJ, Hallez H, Santens P, De Letter M (2013) Neurophysiological investigation of phonological input: aging effects and development of normative data. Brain Lang 125(3):253–263. https://doi.org/10.1016/j.bandl.2013.02.010 - DOI - PubMed
    1. Arheix-Parras S, Barrios C, Python G, Cogné M, Sibon I, Engelhardt M, Dehail P, Cassoudesalle H, Moucheboeuf G, Glize B (2021) A systematic review of repetitive transcranial magnetic stimulation in aphasia rehabilitation: leads for future studies. Neurosci Biobehav Rev 127:212–241. https://doi.org/10.1016/j.neubiorev.2021.04.008 - DOI - PubMed
    1. Barbancho MA, Berthier ML, Navas-Sánchez P, Dávila G, Green-Heredia C, García-Alberca JM, Ruiz-Cruces R, López-González MV, Dawid-Milner MS, Pulvermüller F, Lara JP (2015) Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: an ERP study. Brain Lang 145–146:1–10. https://doi.org/10.1016/j.bandl.2015.04.003 - DOI - PubMed
    1. Barwood CHS, Murdoch BE, Whelan B-M, Lloyd D, Riek S, O’Sullivan JD, Coulthard A, Wong A (2011) Modulation of N400 in chronic non-fluent aphasia using low frequency repetitive transcranial magnetic stimulation (rTMS). Brain Lang 116(3):125–135. https://doi.org/10.1016/j.bandl.2010.07.004 - DOI - PubMed

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