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Review
. 2023 Oct;133(4):286-294.
doi: 10.1111/bcpt.13841. Epub 2023 Feb 17.

The adhesion G protein-coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes

Cheng-Chih Hsiao  1   2 , Els Vos  1   2 , Klaas P J M van Gisbergen  3 , Jörg Hamann  1   2
Affiliations
Free article
Review

The adhesion G protein-coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes

Cheng-Chih Hsiao et al. Basic Clin Pharmacol Toxicol. 2023 Oct.
Free article

Abstract

GPR56/ADGRG1 is an adhesion G protein-coupled receptor connected to brain development, haematopoiesis, male fertility, and tumorigenesis. Nevertheless, expression of GPR56 is not restricted to developmental processes. Studies over the last years have demonstrated a marked presence of GPR56 in human cytotoxic NK and T cells. Expression of GPR56 in these cells is driven by the transcription factor HOBIT, corresponds with the production of cytolytic mediators and the presence of CX3 CR1 and CD57, indicates a state of terminal differentiation and cellular exhaustion, and disappears upon cellular activation. Functional studies indicate that GPR56 regulates cell migration and effector functions and thereby acts as an inhibitory immune checkpoint. We here discuss the current state of knowledge regarding GPR56 in cytotoxic lymphocytes.

Keywords: adhesion G protein-coupled receptor; cytotoxic lymphocytes; immune checkpoint.

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References

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