Drugging a metabolic vulnerability in glioblastoma

Comment

Katie Kingwell. Nat Rev Drug Discov. 2023 Mar.

. 2023 Mar;22(3):182.

doi: 10.1038/d41573-023-00020-0.

No abstract available

Comment on

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.
Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE. Eyme KM, et al. Sci Transl Med. 2023 Jan 18;15(679):eabq6288. doi: 10.1126/scitranslmed.abq6288. Epub 2023 Jan 18. Sci Transl Med. 2023. PMID: 36652537 Free PMC article.

1. Eyme, K. M. et al. Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models. Sci. Transl Med. 15, eabq6288 (2023) - PubMed - DOI