Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Jan 5;15(1):e33400.
doi: 10.7759/cureus.33400. eCollection 2023 Jan.

Kidney Transplantation in a Patient Affected by Sickle Cell Trait: A Case Report and State-of-the-Art Review

Affiliations
Case Reports

Kidney Transplantation in a Patient Affected by Sickle Cell Trait: A Case Report and State-of-the-Art Review

Daniela Picciotto et al. Cureus. .

Abstract

Chronic kidney disease (CKD) is a common feature of sickle cell disease (SCD). The awareness of the clinical presentation and renal involvement in patients affected by hemoglobinopathies is greatly needed. Patient management is particularly complex, especially with kidney transplantation. We, therefore, report the case of a 56-year-old patient affected by sickle cell trait who underwent kidney transplantation. This case will underline all the various challenges the nephrologist must face in this clinical setting and their management.

Keywords: hemoglobinopathy; hereditary nephropathies; immunological risk; infectious complications; kidney transplantation; sickle cell anemia; sickle cell trait; sickle hemoglobin.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. The morbidity and mortality of end stage renal disease in sickle cell disease. Viner M, Zhou J, Allison D, et al. Am J Hematol. 2019;94:0–41. - PMC - PubMed
    1. Renal abnormalities in sickle cell disease. Pham PT, Pham PC, Wilkinson AH, Lew SQ. Kidney Int. 2000;57:1–8. - PubMed
    1. Glomerular lesions in patients with sickle cell disease. Maigne G, Ferlicot S, Galacteros F, et al. Medicine. 2010;89:18–27. - PubMed
    1. Outcome and challenges of kidney transplant in patients with sickle cell disease. Okafor UH, Aneke E. J Transplant. 2013;2013:614610. - PMC - PubMed
    1. The current state of sickle cell trait: implications for reproductive and genetic counseling. Pecker LH, Naik RP. Blood. 2018;132:2331–2338. - PMC - PubMed

Publication types

LinkOut - more resources