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. 2022 Sep;18(3):261-268.
doi: 10.5114/aic.2022.120451. Epub 2022 Oct 19.

Quality of life after percutaneous paravalvular leak closure - a prospective registry

Michal Kozlowski  1 , Magdalena Malczewska  2 , Piotr Pysz  3 , Marek Jędrzejek  1 , Wojciech Wojakowski  1 , Grzegorz Smolka  1
Affiliations

Quality of life after percutaneous paravalvular leak closure - a prospective registry

Michal Kozlowski et al. Postepy Kardiol Interwencyjnej. 2022 Sep.

Abstract

Introduction: Presence of paravalvular leaks (PVLs) can lead to heart failure, which decreases quality of life (QoL). Percutaneous closure is becoming the first-line treatment of PVLs, but whether such a procedure could improve QoL in these patients has never been examined.

Aim: To examine changes in scores of the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Kansas City Cardiomyopathy Questionnaire (KCCQ) after percutaneous PVL closure.

Material and methods: Forty subjects with heart failure symptoms and at least moderate PVL were included in this prospective registry. QoL was assessed at baseline and during a 12-month follow-up after percutaneous PVL closure by MLHFQ and KCCQ questionnaires. Changes in NT-proBNP and lactate dehydrogenase (LDH) levels were also analyzed.

Results: Technical success (TS) was achieved in 97.5% of cases and procedural success (PS) in 85% of cases. In the group with PS a significant decrease in MLHFQ score as well as an increase in scores of all KCCQ domains was observed. No statistically significant changes were observed in the group without PS, mainly due to the small sample size.

Conclusions: Percutaneous PVL closure is associated with better QoL during a 12-month follow-up provided PS was achieved. Due to the low number of subjects in whom PS was not achieved, it is not possible to determine the influence of a failed procedure in this group of patients.

Keywords: heart failure; paravalvular leak; quality of life; structural heart diseases.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study flowchart
Figure 2
Figure 2
Comparison of MLHFQ mean scores in subgroup of patients with echocardiographic success
Figure 3
Figure 3
Comparison of MLHFQ mean scores in subgroup of patients without echocardiographic success
Figure 4
Figure 4
Comparison of KCCQ quality of life mean scores in subgroup of patients with echocardiographic success
Figure 5
Figure 5
Comparison of KCCQ quality of life mean scores in subgroup of patients without echocardiographic success
Figure 6
Figure 6
Comparison of KCCQ mean overall summary scores in subgroup of patients with echocardiographic success
Figure 7
Figure 7
Comparison of KCCQ mean overall summary scores in a subgroup of patients with no echocardiographic success
Figure 8
Figure 8
Comparison of NT-proBNP mean concentrations in subgroup of patients with echocardiographic success
Figure 9
Figure 9
Comparison of NT-proBNP mean concentrations in a subgroup of patients with no echocardiographic success
See this image and copyright information in PMC

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