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. 2023 Jan 25;7(2):e828.
doi: 10.1097/HS9.0000000000000828. eCollection 2023 Feb.

Quantitative Assessment of Vacuolization of Myeloid Precursors in VEXAS Syndrome

Audrey Rabut  1 , Ludivine Jasserand  1 , Camille Richard  2 , Cecile Dumas  3 , Fanélie Mestrallet  4 , Estelle Bourbon  1 , Mathieu Gerfaud Valentin  5   6 , Maël Heiblig  7   8 , Marion Eveillard  2   5 , Yvan Jamilloux  6   9 , Pierre Sujobert  1   8
Affiliations

Quantitative Assessment of Vacuolization of Myeloid Precursors in VEXAS Syndrome

Audrey Rabut et al. Hemasphere. .
No abstract available

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Figures

Figure 1.
Figure 1.
Quantitative assessment of vacuolization of myeloid precursors. Relative proportions of vacuolized cells and mean number of vacuoles/cell in early neutrophil precursors (A and C), early erythroid precursors (B and D) in the exploratory cohort of 17 UBA1-mutated patients and 15 UBA1-WT. ***P < 0.001.
Figure 2.
Figure 2.
Establishment and validation of a diagnostic threshold. Graphical distribution of UBA1-mutated patients (red dots) and UBA1-WTpatients (blue dots) in the exploratory (A) and validation (B) cohorts according to their proportion of vacuolized cells in early erythroid and neutrophilic precursors; (C) distribution of VEXAS syndrome cases described in Obiorah et al; (D) distribution of cases according to the nature of the mutation.
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