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Review
. 2023 Feb 15;24(2):101-114.
doi: 10.1631/jzus.B2200178.

Multiple characteristic alterations and available therapeutic strategies of cellular senescence

[Article in English, Chinese]
Yunzi Zhao  1 , Hui Li  1 , Qinglong Guo  1 , Hui Hui  2
Affiliations
Review

Multiple characteristic alterations and available therapeutic strategies of cellular senescence

[Article in English, Chinese]
Yunzi Zhao et al. J Zhejiang Univ Sci B. .

Abstract
in English, Chinese, Chinese

Given its state of stable proliferative inhibition, cellular senescence is primarily depicted as a critical mechanism by which organisms delay the progression of carcinogenesis. Cells undergoing senescence are often associated with the alteration of a series of specific features and functions, such as metabolic shifts, stemness induction, and microenvironment remodeling. However, recent research has revealed more complexity associated with senescence, including adverse effects on both physiological and pathological processes. How organisms evade these harmful consequences and survive has become an urgent research issue. Several therapeutic strategies targeting senescence, including senolytics, senomorphics, immunotherapy, and function restoration, have achieved initial success in certain scenarios. In this review, we describe in detail the characteristic changes associated with cellular senescence and summarize currently available countermeasures.

衰老的细胞通常处于一种稳定的增殖抑制状态，因此细胞衰老最初被认为是生物体延缓癌症进展的重要机制。细胞在衰老时通常伴随着一系列特征和功能的改变，如代谢迁移、干性诱导以及微环境重塑等。然而，近年来研究表明，细胞衰老参与了机体一系列生理学和病理学的变化，进一步增加了其复杂性。生物体如何通过适应性变化来规避衰老带来的不利影响是当前研究的热点之一。目前，针对细胞衰老的疗法，包括衰老细胞裂解、衰老形态学纠正、衰老免疫疗法以及功能恢复等，已经在特定的情境下取得初步成果。在这篇综述中，我们详细描述了细胞衰老相关的特征变化，并总结了当前衰老治疗可行的策略。.

衰老的细胞通常处于一种稳定的增殖抑制状态，因此细胞衰老最初被认为是生物体延缓癌症进展的重要机制。细胞在衰老时通常伴随着一系列特征和功能的改变，如代谢迁移、干性诱导以及微环境重塑等。然而，近年来研究表明，细胞衰老参与了机体一系列生理学和病理学的变化，进一步增加了其复杂性。生物体如何通过适应性变化来规避衰老带来的不利影响是当前研究的热点之一。目前，针对细胞衰老的疗法，包括衰老细胞裂解、衰老形态学纠正、衰老免疫疗法以及功能恢复等，已经在特定的情境下取得初步成果。在这篇综述中，我们详细描述了细胞衰老相关的特征变化，并总结了当前衰老治疗可行的策略。

Keywords: Immune surveillance; Metabolism; Microenvironment; Senescence; Senolytic; Stemness.

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Figures

Fig. 1
Fig. 1. Senescence-associated alterations and therapeutic strategies. Senescent cells (in the middle) with SASP undergo a series of specific property and function changes (on the left). Currently available therapeutic strategies are shown on the right. SASP: senescence-associated secretory phenotype; ADC: antibody-drug conjugate; CAR-T: chimeric antigen receptor (CAR)-T cell therapy; CAR-NK: CAR-natural killer cell therapy; SC: stem cell; EVs: extracellular vesicles.
See this image and copyright information in PMC

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