Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;147(4):373-388.
doi: 10.1111/acps.13535. Epub 2023 Mar 1.

Physical and mental health status of former smokers and non-smokers patients with bipolar disorder

Bénédicte Nobile  1   2   3 , Ophélia Godin  3   4 , Sébastien Gard  3   5 , Ludovic Samalin  3   6 , Georges Brousse  3   6 , Joséphine Loftus  3   7 , Valérie Aubin  3   7 , Raoul Belzeaux  1   3   8 , Caroline Dubertret  3   9 , Yann Le Strat  3   9 , Nicolas Mazer  3   9 , Alix de Prémorel  3   9 , Paul Roux  3   10 , Mircea Polosan  3   11 , Thomas Schwintzer  3   12   13   14 , Pierre-Michel Llorca  3   6 ; FondaMental Advanced Center of Expertise for Bipolar Disorders (FACE-BD) collaborators  3 ; Isabelle Biseul  3   15 , Bruno Etain  3   15   16 , Remi Moirand  3   17 , Emilie Olié  1   2   3 , Emmanuel Haffen  3   17 , Marion Leboyer  3   18 , Philippe Courtet  1   2   3 , Sébastien Guillaume  1   2   3 , Romain Icick  3   12   13   15   16
Affiliations

Physical and mental health status of former smokers and non-smokers patients with bipolar disorder

Bénédicte Nobile et al. Acta Psychiatr Scand. 2023 Apr.

Abstract

Objectives: Up to 70% individuals with bipolar disorder (BD) are lifetime tobacco smokers, a major modifiable risk factor for morbidity. However, quitting smoking is rarely proposed to individuals with BD, mainly because of fear of unfavorable metabolic or psychiatric changes. Evaluating the physical and mental impact of tobacco cessation is primordial. The aim of this study was to characterize the psychiatric and nonpsychiatric correlates of tobacco smoking status (never- vs. current vs. former smokers) in individuals with BD.

Methods: 3860 individuals with ascertained BD recruited in the network of Fondamental expert centers for BD between 2009 and 2020 were categorized into current, former, and never tobacco smokers. We compared the sociodemographic and clinical characteristics assessed by standard instruments (e.g., BD type, current symptoms load, and non-psychiatric morbidity-including anthropometric and biological data) of the three groups using multinomial regression logistic models. Corrections for multiple testing were applied.

Results: Current smokers had higher depression, anxiety, and impulsivity levels than former and never-smokers, and also higher risk of comorbid substance use disorders with a gradient from never to former to current smokers-suggesting shared liability. Current smokers were at higher risk to have a metabolic syndrome than never-smokers, although this was only evidenced in cases, who were not using antipsychotics.

Conclusions: Tobacco smoking was associated with high morbidity level. Strikingly, as in the general population, quitting smoking seemed associated with their return to the never-smokers' levels. Our findings strongly highlight the need to spread strategies to treat tobacco addiction in the BD population.

Keywords: addiction; bipolar disorder; former smokers; metabolic syndrome; tobacco.

PubMed Disclaimer

References

REFERENCES

    1. 23 and Me Research Team, Walters RK, Polimanti R, et al. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018;21:1656-1669. doi:10.1038/s41593-018-0275-1
    1. Anthenelli RM, Benowitz NL, West R, et al. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. Lancet. 2016;387:2507-2520. doi:10.1016/S0140-6736(16)30272-0
    1. Augustin M, Schoretsanitis G, Pfeifer P, Gründer G, Liebe C, Paulzen M. Effect of fluvoxamine augmentation and smoking on clozapine serum concentrations. Schizophr Res. 2019;210:143-148. doi:10.1016/j.schres.2019.05.033
    1. Baylé FJ, Bourdel MC, Caci H, et al. Structure factorielle de la traduction française de l'échelle d'impulsivité de Barratt (BIS-10). Can J Psychiatry. 2000;45:156-165. doi:10.1177/070674370004500206
    1. Berk M, Ng F, Wang WV, et al. Going up in smoke: tobacco smoking is associated with worse treatment outcomes in mania. J Affect Disord. 2008;110:126-134. doi:10.1016/j.jad.2008.01.018

Publication types