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Review
. 2023 Aug;43(6):2415-2436.
doi: 10.1007/s10571-023-01323-x. Epub 2023 Feb 8.

The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Luyao Xu  1 , Lingyue Li  1 , Qianling Chen  1 , Yuebing Huang  1 , Xuebing Chen  2 , Dongfang Qiao  3
Affiliations
Review

The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Luyao Xu et al. Cell Mol Neurobiol. 2023 Aug.

Abstract

Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the central nervous system (CNS). Repeated intake of METH can lead to addiction, which has become a globalized problem, resulting in multiple public health and safety problems. Recently, the non-coding RNA (ncRNA) has been certified to play an essential role in METH addiction through various mechanisms. Herein, we mainly focused on three kinds of ncRNAs including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which are involved in neurotoxicity effects such as cognitive impairment, behavioral abnormalities, and psychiatric disorders due to METH abuse. In addition, differential expression (DE) ncRNAs also suggest that specific responses and sensitivity to METH neurotoxicity exist in different brain regions and cells. We summarized the relationships between the ncRNAs and METH-induced neurotoxicity and psychiatric disturbances, respectively, hoping to provide new perspectives and strategies for the prevention and treatment of METH abuse. Schematic diagram of the non-coding RNAs (ncRNAs) was involved in methamphetamine (METH)-induced neurotoxicity. The ncRNAs were involved in METH-induced blood-brain barrier disruption, neuronal, astrocyte, and microglial damage, and synaptic neurotransmission impairment. The study of ncRNAs is a hot spot in the future to further understand the neurotoxicity of METH and provide more favorable scientific support for clinical diagnosis and innovation of related treatments.

Keywords: Brain region specificity; Methamphetamine (METH); Methamphetamine-related psychiatric disorders; Neurotoxicity; Non-coding RNA (ncRNA).

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Conflict of interest statement

The authors declare that they have no conflict of interest.

References

    1. Abbott NJ (2002) Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 200(6):629–638 - PMC - PubMed
    1. Akindipe T, Wilson D, Stein DJ (2014) Psychiatric disorders in individuals with methamphetamine dependence: prevalence and risk factors. Metab Brain Dis 29(2):351–357 - PubMed
    1. Ares-Santos S, Granado N, Espadas I, Martinez-Murillo R, Moratalla R (2014) Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining. Neuropsychopharmacology 39(5):1066–1080 - PMC - PubMed
    1. Arzua T, Jiang C, Yan Y, Bai X (2021) The importance of non-coding RNAs in environmental stress-related developmental brain disorders: a systematic review of evidence associated with exposure to alcohol, anesthetic drugs, nicotine, and viral infections. Neurosci Biobehav Rev 128:633–647 - PMC - PubMed
    1. Asanuma M, Tsuji T, Miyazaki I, Miyoshi K, Ogawa N (2003) Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug. Neurosci Lett 352(1):13–16 - PubMed

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