Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Apr;25(4):269-278.
doi: 10.1007/s11912-023-01364-x. Epub 2023 Feb 8.

Translocations and Gene Fusions in Sinonasal Malignancies

Riley Larkin  1   2 , Mario A Hermsen  3 , Nyall R London Jr  4   5   6
Affiliations
Review

Translocations and Gene Fusions in Sinonasal Malignancies

Riley Larkin et al. Curr Oncol Rep. 2023 Apr.

Abstract

Purpose of review: During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of these tumors. The molecular consequences and neo-antigens resulting from these chromosomal aberrations are considered and targets for current and future clinical trials discussed.

Recent findings: Several new, clinically relevant, chromosomal aberrations have been discovered and evaluated to varying degrees in sinonasal tumors including DEK::AFF2, BRD4::NUT, ADCK4::NUMBL, and ETV6::NTRK3. Sinonasal malignancies demonstrate a diverse genetic landscape and varying clinical courses. Recent studies illustrate that gene fusions and translocations may play a role in carcinogenesis in certain sinonasal tumor subtypes and may be used to develop new biomarker-driven and patient-centered treatments.

Keywords: Chimeric protein; Gene fusion; Neo-antigen; Sinonasal malignancies; Translocation.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

All other authors declare no competing interests.

References

    1. Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck. 2012;34(6):877–85. doi: 10.1002/hed.21830. - DOI - PubMed
    1. Sanghvi S, Khan MN, Patel NR, Yeldandi S, Baredes S, Eloy JA. Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients. Laryngoscope. 2014;124(1):76–83. doi: 10.1002/lary.24264. - DOI - PubMed
    1. Dutta R, Dubal PM, Svider PF, Liu JK, Baredes S, Eloy JA. Sinonasal malignancies: A population-based analysis of site-specific incidence and survival. Laryngoscope. 2015;125(11):2491–7. doi: 10.1002/lary.25465. - DOI - PubMed

    1. Hermsen MA, Riobello C, García-Marín R, Cabal VN, Suárez-Fernández L, López F, et al. Translational genomics of sinonasal cancers. Semin Cancer Biol. 2020;61:101–9. doi: 10.1016/j.semcancer.2019.09.016.

      •• A comprehensive overview of the genetics of sinonasal tumors; exploring histology, clinical features, and many potential actionable mutations for targeted therapies.

    1. Board PDQATE. Paranasal Sinus and Nasal Cavity Cancer Treatment (Adult) (PDQ®): Health Professional Version. PDQ Cancer Information Summaries. Bethesda (MD): National Cancer Institute (US); 2002. - PubMed

Publication types

MeSH terms