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Meta-Analysis
. 2023 Jan 1;50(1):e227873.
doi: 10.14503/THIJ-22-7873.

Impact of Chronic Kidney Disease on Outcomes of Percutaneous Coronary Intervention in Patients With Diabetes Mellitus: A Systematic Review and Meta-Analysis

Wei Jiang  1 , Yudi Zhou  1 , Shu Chen  2 , Shengxin Liu  3
Affiliations
Meta-Analysis

Impact of Chronic Kidney Disease on Outcomes of Percutaneous Coronary Intervention in Patients With Diabetes Mellitus: A Systematic Review and Meta-Analysis

Wei Jiang et al. Tex Heart Inst J. .

Abstract

Background: The impact of chronic kidney disease (CKD) on adverse cardiovascular outcomes after percutaneous coronary intervention in patients with diabetes mellitus (DM) is still unclear. This study aimed to systematically assess evidence on this topic.

Methods: The PubMed, Embase, and CENTRAL databases were searched for studies comparing mortality, myocardial infarction (MI), or revascularization outcomes between patients with DM with and without CKD.

Results: In 11 studies, the presence of CKD was associated with significantly increased risk of early all-cause mortality (risk ratio [RR], 3.45; 95% CI, 3.07-3.87; I2 = 0%; P < .001), late all-cause mortality (RR, 2.78; 95% CI, 1.92-4.02; I2 = 83%; P < .001), cardiac mortality (RR, 2.90; 95% CI, 1.99-4.22; I2 = 29%; P < .001), and MI (RR, 1.40; 95% CI, 1.06-1.85; I2 = 13%; P = .02) compared with no CKD. There was no difference in the risk of any revascularization between those with and without CKD. Analysis of adjusted hazard ratios (HRs) indicated significantly increased risk of mortality (HR, 2.64; 95% CI, 1.91-3.64; I2 = 0%; P < .001) in the CKD group but only a nonsignificant tendency of increased MI (HR, 1.59; 95% CI, 0.99-2.54; I2 = 0%; P = .05) and revascularization (HR, 1.24; 95% CI, 0.94-1.63; I2 = 2%; P = .12) in the CKD group.

Conclusion: The presence of CKD in patients with DM significantly increases the risk of mortality and MI. However, CKD had no impact on revascularization rates.

Keywords: Renal failure; coronary artery disease; diabetes mellitus; kidney disease; mortality.

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Conflict of interest statement

Conflict of Interest Disclosures: None

Figures

Fig. 1
Fig. 1
Study flow chart.
Fig. 2
Fig. 2
Results of the meta-analysis of early and late all-cause mortality between patients with diabetes mellitus with and without CKD. The total number of patients in Liosis et al excludes patients lost to follow-up. P < .05 was considered statistically significant. CKD, chronic kidney disease; df, degree of freedom; IV, inverse variance.
Fig. 3
Fig. 3
Funnel plot for the meta-analysis of mortality between patients with diabetes mellitus with and without chronic kidney disease. RR, risk ratio.
Fig. 4
Fig. 4
Meta-analysis of A) cardiac mortality, B) myocardial infarction, and C) revascularization between patients with diabetes mellitus with and without CKD. P < .05 was considered statistically significant. CKD, chronic kidney disease; df, degree of freedom; IV, inverse variance.
See this image and copyright information in PMC

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