GDF15 analogs as obesity therapeutics

Samuel N Breit¹, David A Brown², Vicky Wang Wei Tsai³

Affiliations

¹ St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital, Sydney and University of New South Wales, Sydney, NSW 2010, Australia. Electronic address: s.breit@unsw.edu.au.
² Department of Immunopathology, Institute for Clinical Pathology and Medical Research-New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia.
³ St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital, Sydney and University of New South Wales, Sydney, NSW 2010, Australia.

PMID: 36754014
DOI: 10.1016/j.cmet.2023.01.002

Free article

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GDF15 analogs as obesity therapeutics

Samuel N Breit et al. Cell Metab. 2023.

Free article

. 2023 Feb 7;35(2):227-228.

doi: 10.1016/j.cmet.2023.01.002.

Authors

Samuel N Breit¹, David A Brown², Vicky Wang Wei Tsai³

Affiliations

¹ St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital, Sydney and University of New South Wales, Sydney, NSW 2010, Australia. Electronic address: s.breit@unsw.edu.au.
² Department of Immunopathology, Institute for Clinical Pathology and Medical Research-New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia.
³ St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital, Sydney and University of New South Wales, Sydney, NSW 2010, Australia.

PMID: 36754014
DOI: 10.1016/j.cmet.2023.01.002

Abstract

There is increasing interest in GDF15 analogs as therapeutic agents for obesity. In this issue of Cell Metabolism, Benichou et al. report the first clinical trial of such a drug in obese humans.

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Conflict of interest statement

Declaration of interests S.N.B. and D.A.B. are inventors on patents owned by St. Vincent’s Hospital that pertain to the clinical use of GDF15.

Comment on

Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist.
Benichou O, Coskun T, Gonciarz MD, Garhyan P, Adams AC, Du Y, Dunbar JD, Martin JA, Mather KJ, Pickard RT, Reynolds VL, Robins DA, Zvada SP, Emmerson PJ. Benichou O, et al. Cell Metab. 2023 Feb 7;35(2):274-286.e10. doi: 10.1016/j.cmet.2022.12.011. Epub 2023 Jan 10. Cell Metab. 2023. PMID: 36630958

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GDF15 analogs as obesity therapeutics

Affiliations

GDF15 analogs as obesity therapeutics

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical