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Comment
. 2023 Feb 7;35(2):228-230.
doi: 10.1016/j.cmet.2023.01.008.

Salty Treg cells get out of balance

Iosif Papafragkos  1 , Panayotis Verginis  2
Affiliations
Free article
Comment

Salty Treg cells get out of balance

Iosif Papafragkos et al. Cell Metab. .
Free article

Abstract

Although metabolic rewiring of Treg cells constitutes a hallmark in autoimmune diseases, extrinsic and intrinsic mechanisms that imprint on this re-programming remain poorly understood. In this issue of Cell Metabolism, Côrte-Real and colleagues demonstrate that high salt exposure disturbs the mitochondrial respiration in Treg cells, promoting a pro-inflammatory phenotype, loss of function, and associated breakdown of self-tolerance.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
    Côrte-Real BF, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen MW, Kurniawan H, Wagner A, Yosef N, Weiss SNY, Schmetterer KG, Schröder A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois LJ, Brenner D, Kempa S, Hafler DA, Stegbauer J, Linker RA, Jantsch J, Müller DN, Kleinewietfeld M. Côrte-Real BF, et al. Cell Metab. 2023 Feb 7;35(2):299-315.e8. doi: 10.1016/j.cmet.2023.01.009. Cell Metab. 2023. PMID: 36754020

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