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Comment
. 2023 Feb 7;35(2):233-235.
doi: 10.1016/j.cmet.2023.01.007.

Metabolic individuality: Limitations, challenges, and potential for clinical utility

Sarah H Elsea  1 , Jennifer E Posey  2
Affiliations
Free article
Comment

Metabolic individuality: Limitations, challenges, and potential for clinical utility

Sarah H Elsea et al. Cell Metab. .
Free article

Abstract

In Nature Medicine, Surendran and colleagues recently reported the analysis of human plasma metabolomic data for 913 metabolites in ∼20,000 individuals, identifying 2,599 metabolite-genetic variant associations and >400 metabolite signatures comprised of jointly regulated metabolites. This extensive atlas of variant-metabolite relationships reveals novel genomic mechanisms driving metabolic phenotypes.

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Conflict of interest statement

Declaration of interests S.H.E. and J.E.P. are employees of Baylor College of Medicine, which derives revenue from genetic and metabolomic testing.

Comment on

  • Rare and common genetic determinants of metabolic individuality and their effects on human health.
    Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J, Rossi N, Sheridan PA, Watkins NA, Mangino M, Hysi PG, Di Angelantonio E, Falchi M, Spector TD, Soranzo N, Michelotti GA, Arlt W, Lotta LA, Denaxas S, Hemingway H, Gamazon ER, Howson JMM, Wood AM, Danesh J, Wareham NJ, Kastenmüller G, Fauman EB, Suhre K, Butterworth AS, Langenberg C. Surendran P, et al. Nat Med. 2022 Nov;28(11):2321-2332. doi: 10.1038/s41591-022-02046-0. Epub 2022 Nov 10. Nat Med. 2022. PMID: 36357675 Free PMC article.

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