Revisiting nanoparticle transendothelial migration in the liver

Affiliations

¹ Associate Editor - Molecular Therapy; School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, UK; Translational and Clinical Research Institute, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: seyed.moghimi@ncl.ac.uk.
² Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
³ Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Editorial

Seyed Moein Moghimi et al. Mol Ther. 2023.

. 2023 Mar 1;31(3):605-606.

doi: 10.1016/j.ymthe.2023.01.024. Epub 2023 Feb 7.

¹ Associate Editor - Molecular Therapy; School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, UK; Translational and Clinical Research Institute, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: seyed.moghimi@ncl.ac.uk.
² Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
³ Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

No abstract available

References

1. Akinc A., Maier M.A., Manoharan M., Fitzgerald K., Jayaraman M., Barros S., Ansell S., Du X., Hope M.J., Madden T.D., et al. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nat. Nanotechnol. 2019;14:1084–1087. doi: 10.1038/s41565-019-0591-y. - DOI - PubMed
1. Snoeys J., Lievens J., Wisse E., Jacobs F., Duimel H., Collen D., Frederik P., De Geest B. Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae. Gene Ther. 2007;14:604–612. doi: 10.1038/sj.gt.3302899. - DOI - PubMed
1. Wisse E., Jacobs F., Topal B., Frederik P., De Geest B. The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer. Gene Ther. 2008;15:1193–1199. doi: 10.1038/gt.2008.60. - DOI - PubMed
1. Fraser R., Cogger V.C., Dobbs B., Jamieson H., Warren A., Hilmer S.N., Le Couteur D.G. The liver sieve and atherosclerosis. Pathology (Phila.) 2012;44:181–186. doi: 10.1097/PAT.0b013e328351bcc8. - DOI - PubMed
1. Cogger V.C., Warren A., Fraser R., Ngu M., McLean A.J., Le Couteur D.G. Hepatic sinusoidal pseudocapillarization with aging in the non-human primate. Exp. Gerontol. 2003;38:1101–1107. doi: 10.1016/j.exger.2003.07.002. - DOI - PubMed