Randomized Controlled Trial
doi: 10.1016/j.ahj.2023.01.018.
Epub 2023 Feb 7.
Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial
David Conen
1
, Ekaterine Popova
2
, Michael Ke Wang
3
, Matthew T V Chan
4
, Giovanni Landoni
5
, Cara Reimer
6
, Sadeesh K Srinathan
7
, Juan P Cata
8
, Sean R McLean
9
, Juan Carlos Trujillo Reyes
10
, Ascensión Martín Grande
11
, Anna Gonzalez Tallada
12
, Daniel I Sessler
13
, Edith Fleischmann
14
, Donna E Maziak
15
, Barbara Kabon
14
, Luca Voltolini
16
, Laura Gutiérrez-Soriano
17
, Vikas Tandon
18
, Deborah DuMerton
6
, Biniam Kidane
19
, Ravi Rajaram
20
, Yaron Shargall
21
, John D Neary
18
, Jennifer R Wells
22
, William F McIntyre
3
, Steffen Blum
23
, Sandra N Ofori
24
, Jessica Vincent
22
, Lizhen Xu
25
, Zhuoru Li
22
, Jeff S Healey
25
, Amit X Garg
26
, P J Devereaux
3
; COP-AF Investigators
Collaborators,
Affiliations
Collaborators
-
COP-AF Investigators:
Devereaux 27 , Jessica Vincent 28 , Michael Ke Wang 27 , Jennifer R Wells 28 , David Conen 27 , P J Devereaux 27 , Jeff S Healey 29 , Giovanni Landoni 5 , William F McIntyre 27 , Ekaterine Popova 2 , Daniel I Sessler 30 , Sadeesh K Srinathan 31 , Jessica Vincent 28 , Michael Ke Wang 27 , Jennifer R Wells 28 , P J Devereaux 27 , Mohammed Amir 32 , Shrikant I Bangdiwala 33 , Matthias Bossard 34 , Matthew T V Chan 4 , John W Eikelboom 29 , Edith Fleischmann 35 , Jeff S Healey 29 , Sanjit S Jolly 27 , Giovanni Landoni 5 , William F McIntyre 27 , Felix Ramón Montes 36 , Ekaterine Popova 2 , Cara Reimer 37 , Denis Schmartz 38 , Daniel I Sessler 30 , Sadeesh K Srinathan 31 , Jessica Vincent 28 , Chew Yin Wang 39 , Michael Ke Wang 27 , Jennifer R Wells 28 , William F McIntyre 27 , Jesus Alvarez-Garcia 40 , Giuliana Lo Bianco 41 , Steffen Blum 42 , Danielle de Sa Boasquevisque 29 , Flavia K Borges 27 , Helene Chiarella-Redfern 43 , Aranzazu Gonzalez-Osuna 44 , Jose M Guerra-Ramos 45 , Maura Marcucci 27 , Pascal B Meyre 46 , Sandra N Ofori 47 , Christopher Oleynick 43 , Anna Ramos-Pachón 48 , Hugh Traquair 49 , Michael Ke Wang 27 , L Brent Mitchell 50 , George Wyse 28 , Davy Cheng 51 , Finlay A McAlister 52 , George A Wells 53 , Geethan Baskaran 28 , Julia Gennaccaro 28 , Rosemary Howe 28 , Louise Mastrangelo 28 , Shirley Pettit 28 , Subana Shahbaz 28 , Makayla Tosh 28 , Jessica Vincent 28 , Jennifer R Wells 28 , Simona J Zucchetto 28 , Shrikant I Bangdiwala 33 , Laura Heenan 28 , Shun Fu Lee 29 , Zhuoru Li 28 , Lizhen Xu 29 , Mohammed Amir 32 , Matthias Bossard 34 , Matthew T V Chan 4 , Edith Fleischmann 35 , Giovanni Landoni 5 , Felix Ramón Montes 36 , Ekaterine Popova 2 , Denis Schmartz 38 , Daniel I Sessler 30 , Chew Yin Wang 39 , Barbara Kabon 35 , Edith Fleischmann 35 , Christian Reiterer 54 , Alexander Taschner 54 , Katharina Horvath 54 , Nikolas Adamowitsch 54 , Oliver Zotti 54 , Nicole Hantáková 54 , Beatrix Hochreiter 54 , Denis Schmartz 38 , Isabelle Huybrechts 55 , Serge Cappeliez 56 , John D Neary 49 , Yaron Shargall 57 , Vikas Tandon 49 , Christian Finley 58 , John Agzarian 58 , Waël Hanna 58 , Muammar Abdulrahman 58 , Kelly Lawrence 58 , Krysten Gregus 58 , Faraaz Quraishi 58 , Spencer Wikkerink 58 , Christine Wallace 58 , Merissa Prine 58 , Emily Gregus 58 , Jacqueline Hare 58 , Kristen Lombardo 58 , Behashta Fezia 58 , Teresa Columbus 58 , Cara Reimer 37 , Deborah DuMerton 37 , Ken Reid 37 , Joel Parlow 37 , Wiley Chung 37 , Maria Karizhenskaia 37 , Aftab Malik 37 , Sadeesh K Srinathan 31 , Biniam Kidane 59 , Richard Liu 60 , Lawrence Tan 60 , Stephen Gowing 60 , Gordon Buduhan 60 , Stephanie Enns 60 , Emma Poole 60 , Kristin Graham 60 , Sean R McLean 61 , Anna McGuire 62 , Jens Lohser 62 , Shirley Lim 62 , Rebecca Grey 62 , Kyle Grant 62 , Alex L Lee 62 , James J Choi 62 , Leith R Dewar 62 , John Yee 62 , Donna E Maziak 63 , Andrew J E Seely 64 , Sebastien Gilbert 64 , P James Villeneuve 64 , Sudhir Sundaresan 64 , Susan D Moffatt-Bruce 64 , Molly Gingrich 64 , Anna Fazekas 64 , Kirby Bucciero 64 , Richard A Malthaner 65 , Deb Lewis 65 , Dalilah Fortin 65 , Mehdi Qiabi 65 , Rahul Nayak 65 , Madelaine Marie Plourde 66 , Daniel Sellers 67 , Laura Donahoe 67 , Marco Lefebvre 68 , Luc Lanthier 68 , Colin Schieman 69 , Amal Bessissow 70 , Matthew T V Chan 4 , Gavin M Joynt 4 , Randolph H L Wong 4 , Rainbow W H Lau 4 , Wai Tat Wong 4 , Gordon Y S Choi 4 , Eva Lee 4 , Ka Yan Hui 4 , Beaker Fung 4 , Chee Sam Chan 4 , Laura Gutiérrez-Soriano 36 , Felix Ramón Montes 36 , Laura Carmenza Castañeda 71 , Luis Jaime Téllez 71 , Lina Marcela Ortiz-Ramirez 71 , Giovanni Landoni 5 , Simona De Santis 72 , Giovanni Favaro 72 , Piergiorgio Muriana 72 , Cristina Nakhnoukh 72 , Pierluigi Novellis 72 , Stefano Turi 72 , Giulia Veronesi 72 , Matteo Angelini 72 , Luca Voltolini 16 , Stefano Bongiolatti 73 , Alberto Salvicchi 73 , Lavinia Gatteschi 73 , Rossella Indino 73 , Simone Tombelli 73 , Alice Ravasin 73 , Ottavia Salimbene 73 , Giulio Luca Rosboch 74 , Eleonora Balzani 74 , Domenico Massullo 75 , Silvia Fiorelli 75 , Francesco Londero 76 , William Grossi 76 , Chew Yin Wang 39 , Tyng Yan Ng 39 , Woan Shiang See 77 , Mohammed Amir 32 , Mohammed Asghar Nawaz 78 , Juan Carlos Trujillo Reyes 10 , Ekaterine Popova 2 , Elisabeth Martinez Tellez 79 , Josep Belda Sanchis 79 , Georgina Planas Cánovas 79 , Ana Parera Ruiz 79 , Esther Cladellas Gutierrez 79 , Mauro Guarino 79 , Gerard Urrutia Cuchi 79 , Marta Argilaga Nogues 79 , Anna Rovira Juan 79 , Jose M Guerra-Ramos 45 , Jesus Alvarez-Garcia 40 , Aranzazu Gonzalez-Osuna 44 , Melixa Medina-Aedo 79 , Ascensión Martín Grande 11 , Diego Parise Roux 11 , Luis Gajate Martín 11 , Angélica De Pablo Pajares 11 , Angel Manuel Candela Toha 11 , Nicolás Moreno Mata 11 , Gema Muñoz Molina 11 , Usue Caballero Silva 11 , Alberto Cabañero 11 , Sara Fra Fernandez 11 , Anna Gonzàlez Tallada 12 , Susana González Suarez 80 , Montserrat Ribas Ball 80 , Miriam De Nadal Clanchet 80 , Laura Ruiz-Villa 81 , M M Martí-Ejarque 81 , Mireia Gili-Bueno 81 , Jorge Hernández Ferrández 81 , Neus Pons Llobet 81 , Patricia Cruz 82 , Guillermo Sánchez-Pedrosa 82 , Patricia Duque 82 , Leire Azcárate 82 , Lorena Martín-Albo 82 , Alberto Rodríguez-Fuster 83 , Silvia Bermejo-Martínez 83 , Albert Carramiñana 84 , Matthias Bossard 34 , Fabrizio Minervini 34 , Juan P Cata 85 , Ravi Rajaram 86 , German Corrales 87 , Juan Jose Guerra-Londono 87 , Reza Mehran 87 , Boris Sepesi 87 , Garrett Walsh 87 , Daniel S Cukierman 87 , Bryan E Marchant 88 , Lynne C Harris 88 , Bruce D Cusson 88 , Scott A Miller 88 , Steven C Minear 89 , Camila Teixeira 89 , Mario Pimentel 89 , Andrew M Popoff 90 , Wing Lee Cheung 90 , Kelly Marsack 90 , Sabry Ayad 91 , Jorge Araujo 91 , Tzonghuei H Chen 92 , Michael Essandoh 93 , Jeremy S Poppers 94
Affiliations
- 1 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address: David.conen@phri.ca.
- 2 Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Iberoamerican Cochrane Centre, Barcelona, Spain.
- 3 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
- 4 The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
- 5 Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
- 6 Kingston Health Sciences Centre, Kingston, Ontario, Canada.
- 7 Department of Surgery, University of Manitoba, Winnipeg, Manitoba , Canada.
- 8 Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
- 9 Department of Anesthesia, Vancouver Acute (Vancouver General Hospital and UBC Hospital), The University of British Columbia, Vancouver, British Columbia, Canada; Department of Anesthesia, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada.
- 10 Department of Thoracic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 11 Hospital Universitario Ramón y Cajal, Madrid, Spain.
- 12 Department of Anesthesiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
- 13 Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH.
- 14 Department of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
- 15 University of Ottawa, Ottawa, Ontario, Canada.
- 16 Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy.
- 17 Department of Anesthesiology, Fundación CardioInfantil - Instituto de Cardiología, Bogotá, Colombia.
- 18 Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 19 Departments of Surgery, Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada.
- 20 Department of Cardiothoracic Surgery, The University of Texas - MD Anderson Cancer Center, Houston, TX.
- 21 Division of Thoracic Surgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
- 22 Population Health Research Institute, Hamilton, Ontario, Canada.
- 23 Population Health Research Institute, Hamilton, Ontario, Canada; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
- 24 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; University of Port Harcourt, Choba, Nigeria.
- 25 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 26 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Departments of Medicine, Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
- 27 Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 28 Population Health Research Institute, Hamilton, ON, Canada.
- 29 Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 30 Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, United States.
- 31 Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
- 32 Department of Surgery, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
- 33 Population Health Research Institute, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 34 Luzerner Kantonsspital, Luzern, Switzerland.
- 35 Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
- 36 Department of Anesthesiology, Fundación Cardioinfantil - Instituto de Cardiología, Bogotá, Colombia.
- 37 Kingston Health Sciences Centre, Kingston, ON, Canada.
- 38 H.U.B - Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
- 39 Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
- 40 Department of Cardiology, Hospital Universitario Ramón y Cajal, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain.
- 41 Università Vita-Salute San Raffaele, Milan, Italy.
- 42 Population Health Research Institute, Hamilton, ON, Canada; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
- 43 Division of General Internal Medicine, Department of Medicine, University of Calgary, Calgary, AB, Canada.
- 44 Orthopedic Surgery and Traumatology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 45 Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain; Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain.
- 46 Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.
- 47 Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; University of Port Harcourt, Choba, Nigeria.
- 48 Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 49 Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 50 Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
- 51 School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China.
- 52 Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
- 53 Cardiovascular Research Methods Centre, Faculty of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
- 54 Medical University of Vienna, Vienna, Austria.
- 55 CUB Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
- 56 University Hospital of Charleroi, Charleroi, Belgium.
- 57 Division of Thoracic Surgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 58 St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
- 59 Departments of Surgery, Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.
- 60 Health Sciences Centre, Winnipeg, Winnipeg, MB, Canada.
- 61 Department of Anesthesia, Vancouver Acute (Vancouver General Hospital and UBC Hospital), The University of British Columbia, Vancouver, BC, Canada; Department of Anesthesia, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC, Canada.
- 62 Vancouver General Hospital, Vancouver, BC, Canada.
- 63 University of Ottawa, Ottawa, ON, Canada.
- 64 The Ottawa Hospital, Ottawa, ON, Canada.
- 65 London Health Sciences Centre, London, ON, Canada.
- 66 Victoria General Hospital, Halifax, NS, Canada.
- 67 Toronto General Hospital, Toronto, ON, Canada.
- 68 CIUSSS de l'Estrie - CHUS, Sherbrooke, QC, Canada.
- 69 FFoothills Medical Centre, Calgary, AB, Canada.
- 70 Montreal General Hospital, Montreal, QC, Canada.
- 71 Fundación Cardioinfantil - Instituto de Cardiología, Bogotá, Colombia.
- 72 IRCCS San Raffaele Scientific Institute, Milan, Italy.
- 73 Careggi University Hospital, Florence, Italy.
- 74 A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
- 75 Sant'Andrea Hospital, Rome, Italy.
- 76 S. Maria della Misericordia University Hospital, Udine, Italy.
- 77 Serdang Hospital, Kajang, Malaysia.
- 78 Shifa International Hospital, Islamabad, Pakistan.
- 79 Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 80 Hospital Universitari Vall d'Hebron, Barcelona, Spain.
- 81 Hospital Universitari Sagrat Cor, Grupo Quironsalud, Barcelona, Spain.
- 82 Hospital Universitary Gregorio Marañon, Madrid, Spain.
- 83 Hospital del Mar, Barcelona, Spain.
- 84 Hospital Clínic, Barcelona, Barcelona, Spain.
- 85 Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
- 86 Department of Cardiothoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
- 87 The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
- 88 Atrium Health Wake Forest Baptist, Winston-Salem, NC, United States.
- 89 Cleveland Clinic Florida, Weston, FL, United States.
- 90 Henry Ford Health, Detroit, MI, United States.
- 91 Fairview Hospital, Cleveland Clinic, Cleveland, OH, United States.
- 92 Rhode Island Hospital, Providence, RI, United States.
- 93 The Ohio State University Wexner Medical Center, Columbus, OH, United States.
- 94 Stony Brook University Hospital, Stony Brook, NY, United States.
- PMID: 36754105
- DOI: 10.1016/j.ahj.2023.01.018
Item in Clipboard
Randomized Controlled Trial
Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial
David Conen et al.
Am Heart J.
2023 May.
Display options
Format
doi: 10.1016/j.ahj.2023.01.018.
Epub 2023 Feb 7.
Authors
David Conen
1
, Ekaterine Popova
2
, Michael Ke Wang
3
, Matthew T V Chan
4
, Giovanni Landoni
5
, Cara Reimer
6
, Sadeesh K Srinathan
7
, Juan P Cata
8
, Sean R McLean
9
, Juan Carlos Trujillo Reyes
10
, Ascensión Martín Grande
11
, Anna Gonzalez Tallada
12
, Daniel I Sessler
13
, Edith Fleischmann
14
, Donna E Maziak
15
, Barbara Kabon
14
, Luca Voltolini
16
, Laura Gutiérrez-Soriano
17
, Vikas Tandon
18
, Deborah DuMerton
6
, Biniam Kidane
19
, Ravi Rajaram
20
, Yaron Shargall
21
, John D Neary
18
, Jennifer R Wells
22
, William F McIntyre
3
, Steffen Blum
23
, Sandra N Ofori
24
, Jessica Vincent
22
, Lizhen Xu
25
, Zhuoru Li
22
, Jeff S Healey
25
, Amit X Garg
26
, P J Devereaux
3
; COP-AF Investigators
Collaborators
-
COP-AF Investigators:
Devereaux 27 , Jessica Vincent 28 , Michael Ke Wang 27 , Jennifer R Wells 28 , David Conen 27 , P J Devereaux 27 , Jeff S Healey 29 , Giovanni Landoni 5 , William F McIntyre 27 , Ekaterine Popova 2 , Daniel I Sessler 30 , Sadeesh K Srinathan 31 , Jessica Vincent 28 , Michael Ke Wang 27 , Jennifer R Wells 28 , P J Devereaux 27 , Mohammed Amir 32 , Shrikant I Bangdiwala 33 , Matthias Bossard 34 , Matthew T V Chan 4 , John W Eikelboom 29 , Edith Fleischmann 35 , Jeff S Healey 29 , Sanjit S Jolly 27 , Giovanni Landoni 5 , William F McIntyre 27 , Felix Ramón Montes 36 , Ekaterine Popova 2 , Cara Reimer 37 , Denis Schmartz 38 , Daniel I Sessler 30 , Sadeesh K Srinathan 31 , Jessica Vincent 28 , Chew Yin Wang 39 , Michael Ke Wang 27 , Jennifer R Wells 28 , William F McIntyre 27 , Jesus Alvarez-Garcia 40 , Giuliana Lo Bianco 41 , Steffen Blum 42 , Danielle de Sa Boasquevisque 29 , Flavia K Borges 27 , Helene Chiarella-Redfern 43 , Aranzazu Gonzalez-Osuna 44 , Jose M Guerra-Ramos 45 , Maura Marcucci 27 , Pascal B Meyre 46 , Sandra N Ofori 47 , Christopher Oleynick 43 , Anna Ramos-Pachón 48 , Hugh Traquair 49 , Michael Ke Wang 27 , L Brent Mitchell 50 , George Wyse 28 , Davy Cheng 51 , Finlay A McAlister 52 , George A Wells 53 , Geethan Baskaran 28 , Julia Gennaccaro 28 , Rosemary Howe 28 , Louise Mastrangelo 28 , Shirley Pettit 28 , Subana Shahbaz 28 , Makayla Tosh 28 , Jessica Vincent 28 , Jennifer R Wells 28 , Simona J Zucchetto 28 , Shrikant I Bangdiwala 33 , Laura Heenan 28 , Shun Fu Lee 29 , Zhuoru Li 28 , Lizhen Xu 29 , Mohammed Amir 32 , Matthias Bossard 34 , Matthew T V Chan 4 , Edith Fleischmann 35 , Giovanni Landoni 5 , Felix Ramón Montes 36 , Ekaterine Popova 2 , Denis Schmartz 38 , Daniel I Sessler 30 , Chew Yin Wang 39 , Barbara Kabon 35 , Edith Fleischmann 35 , Christian Reiterer 54 , Alexander Taschner 54 , Katharina Horvath 54 , Nikolas Adamowitsch 54 , Oliver Zotti 54 , Nicole Hantáková 54 , Beatrix Hochreiter 54 , Denis Schmartz 38 , Isabelle Huybrechts 55 , Serge Cappeliez 56 , John D Neary 49 , Yaron Shargall 57 , Vikas Tandon 49 , Christian Finley 58 , John Agzarian 58 , Waël Hanna 58 , Muammar Abdulrahman 58 , Kelly Lawrence 58 , Krysten Gregus 58 , Faraaz Quraishi 58 , Spencer Wikkerink 58 , Christine Wallace 58 , Merissa Prine 58 , Emily Gregus 58 , Jacqueline Hare 58 , Kristen Lombardo 58 , Behashta Fezia 58 , Teresa Columbus 58 , Cara Reimer 37 , Deborah DuMerton 37 , Ken Reid 37 , Joel Parlow 37 , Wiley Chung 37 , Maria Karizhenskaia 37 , Aftab Malik 37 , Sadeesh K Srinathan 31 , Biniam Kidane 59 , Richard Liu 60 , Lawrence Tan 60 , Stephen Gowing 60 , Gordon Buduhan 60 , Stephanie Enns 60 , Emma Poole 60 , Kristin Graham 60 , Sean R McLean 61 , Anna McGuire 62 , Jens Lohser 62 , Shirley Lim 62 , Rebecca Grey 62 , Kyle Grant 62 , Alex L Lee 62 , James J Choi 62 , Leith R Dewar 62 , John Yee 62 , Donna E Maziak 63 , Andrew J E Seely 64 , Sebastien Gilbert 64 , P James Villeneuve 64 , Sudhir Sundaresan 64 , Susan D Moffatt-Bruce 64 , Molly Gingrich 64 , Anna Fazekas 64 , Kirby Bucciero 64 , Richard A Malthaner 65 , Deb Lewis 65 , Dalilah Fortin 65 , Mehdi Qiabi 65 , Rahul Nayak 65 , Madelaine Marie Plourde 66 , Daniel Sellers 67 , Laura Donahoe 67 , Marco Lefebvre 68 , Luc Lanthier 68 , Colin Schieman 69 , Amal Bessissow 70 , Matthew T V Chan 4 , Gavin M Joynt 4 , Randolph H L Wong 4 , Rainbow W H Lau 4 , Wai Tat Wong 4 , Gordon Y S Choi 4 , Eva Lee 4 , Ka Yan Hui 4 , Beaker Fung 4 , Chee Sam Chan 4 , Laura Gutiérrez-Soriano 36 , Felix Ramón Montes 36 , Laura Carmenza Castañeda 71 , Luis Jaime Téllez 71 , Lina Marcela Ortiz-Ramirez 71 , Giovanni Landoni 5 , Simona De Santis 72 , Giovanni Favaro 72 , Piergiorgio Muriana 72 , Cristina Nakhnoukh 72 , Pierluigi Novellis 72 , Stefano Turi 72 , Giulia Veronesi 72 , Matteo Angelini 72 , Luca Voltolini 16 , Stefano Bongiolatti 73 , Alberto Salvicchi 73 , Lavinia Gatteschi 73 , Rossella Indino 73 , Simone Tombelli 73 , Alice Ravasin 73 , Ottavia Salimbene 73 , Giulio Luca Rosboch 74 , Eleonora Balzani 74 , Domenico Massullo 75 , Silvia Fiorelli 75 , Francesco Londero 76 , William Grossi 76 , Chew Yin Wang 39 , Tyng Yan Ng 39 , Woan Shiang See 77 , Mohammed Amir 32 , Mohammed Asghar Nawaz 78 , Juan Carlos Trujillo Reyes 10 , Ekaterine Popova 2 , Elisabeth Martinez Tellez 79 , Josep Belda Sanchis 79 , Georgina Planas Cánovas 79 , Ana Parera Ruiz 79 , Esther Cladellas Gutierrez 79 , Mauro Guarino 79 , Gerard Urrutia Cuchi 79 , Marta Argilaga Nogues 79 , Anna Rovira Juan 79 , Jose M Guerra-Ramos 45 , Jesus Alvarez-Garcia 40 , Aranzazu Gonzalez-Osuna 44 , Melixa Medina-Aedo 79 , Ascensión Martín Grande 11 , Diego Parise Roux 11 , Luis Gajate Martín 11 , Angélica De Pablo Pajares 11 , Angel Manuel Candela Toha 11 , Nicolás Moreno Mata 11 , Gema Muñoz Molina 11 , Usue Caballero Silva 11 , Alberto Cabañero 11 , Sara Fra Fernandez 11 , Anna Gonzàlez Tallada 12 , Susana González Suarez 80 , Montserrat Ribas Ball 80 , Miriam De Nadal Clanchet 80 , Laura Ruiz-Villa 81 , M M Martí-Ejarque 81 , Mireia Gili-Bueno 81 , Jorge Hernández Ferrández 81 , Neus Pons Llobet 81 , Patricia Cruz 82 , Guillermo Sánchez-Pedrosa 82 , Patricia Duque 82 , Leire Azcárate 82 , Lorena Martín-Albo 82 , Alberto Rodríguez-Fuster 83 , Silvia Bermejo-Martínez 83 , Albert Carramiñana 84 , Matthias Bossard 34 , Fabrizio Minervini 34 , Juan P Cata 85 , Ravi Rajaram 86 , German Corrales 87 , Juan Jose Guerra-Londono 87 , Reza Mehran 87 , Boris Sepesi 87 , Garrett Walsh 87 , Daniel S Cukierman 87 , Bryan E Marchant 88 , Lynne C Harris 88 , Bruce D Cusson 88 , Scott A Miller 88 , Steven C Minear 89 , Camila Teixeira 89 , Mario Pimentel 89 , Andrew M Popoff 90 , Wing Lee Cheung 90 , Kelly Marsack 90 , Sabry Ayad 91 , Jorge Araujo 91 , Tzonghuei H Chen 92 , Michael Essandoh 93 , Jeremy S Poppers 94
Affiliations
- 1 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address: David.conen@phri.ca.
- 2 Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Iberoamerican Cochrane Centre, Barcelona, Spain.
- 3 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
- 4 The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
- 5 Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
- 6 Kingston Health Sciences Centre, Kingston, Ontario, Canada.
- 7 Department of Surgery, University of Manitoba, Winnipeg, Manitoba , Canada.
- 8 Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
- 9 Department of Anesthesia, Vancouver Acute (Vancouver General Hospital and UBC Hospital), The University of British Columbia, Vancouver, British Columbia, Canada; Department of Anesthesia, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada.
- 10 Department of Thoracic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 11 Hospital Universitario Ramón y Cajal, Madrid, Spain.
- 12 Department of Anesthesiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
- 13 Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH.
- 14 Department of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
- 15 University of Ottawa, Ottawa, Ontario, Canada.
- 16 Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy.
- 17 Department of Anesthesiology, Fundación CardioInfantil - Instituto de Cardiología, Bogotá, Colombia.
- 18 Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 19 Departments of Surgery, Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada.
- 20 Department of Cardiothoracic Surgery, The University of Texas - MD Anderson Cancer Center, Houston, TX.
- 21 Division of Thoracic Surgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
- 22 Population Health Research Institute, Hamilton, Ontario, Canada.
- 23 Population Health Research Institute, Hamilton, Ontario, Canada; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
- 24 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; University of Port Harcourt, Choba, Nigeria.
- 25 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 26 Population Health Research Institute, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Departments of Medicine, Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
- 27 Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 28 Population Health Research Institute, Hamilton, ON, Canada.
- 29 Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 30 Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, United States.
- 31 Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
- 32 Department of Surgery, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
- 33 Population Health Research Institute, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 34 Luzerner Kantonsspital, Luzern, Switzerland.
- 35 Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
- 36 Department of Anesthesiology, Fundación Cardioinfantil - Instituto de Cardiología, Bogotá, Colombia.
- 37 Kingston Health Sciences Centre, Kingston, ON, Canada.
- 38 H.U.B - Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
- 39 Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
- 40 Department of Cardiology, Hospital Universitario Ramón y Cajal, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain.
- 41 Università Vita-Salute San Raffaele, Milan, Italy.
- 42 Population Health Research Institute, Hamilton, ON, Canada; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
- 43 Division of General Internal Medicine, Department of Medicine, University of Calgary, Calgary, AB, Canada.
- 44 Orthopedic Surgery and Traumatology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 45 Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain; Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain.
- 46 Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.
- 47 Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; University of Port Harcourt, Choba, Nigeria.
- 48 Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 49 Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 50 Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
- 51 School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China.
- 52 Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
- 53 Cardiovascular Research Methods Centre, Faculty of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
- 54 Medical University of Vienna, Vienna, Austria.
- 55 CUB Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
- 56 University Hospital of Charleroi, Charleroi, Belgium.
- 57 Division of Thoracic Surgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- 58 St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
- 59 Departments of Surgery, Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.
- 60 Health Sciences Centre, Winnipeg, Winnipeg, MB, Canada.
- 61 Department of Anesthesia, Vancouver Acute (Vancouver General Hospital and UBC Hospital), The University of British Columbia, Vancouver, BC, Canada; Department of Anesthesia, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC, Canada.
- 62 Vancouver General Hospital, Vancouver, BC, Canada.
- 63 University of Ottawa, Ottawa, ON, Canada.
- 64 The Ottawa Hospital, Ottawa, ON, Canada.
- 65 London Health Sciences Centre, London, ON, Canada.
- 66 Victoria General Hospital, Halifax, NS, Canada.
- 67 Toronto General Hospital, Toronto, ON, Canada.
- 68 CIUSSS de l'Estrie - CHUS, Sherbrooke, QC, Canada.
- 69 FFoothills Medical Centre, Calgary, AB, Canada.
- 70 Montreal General Hospital, Montreal, QC, Canada.
- 71 Fundación Cardioinfantil - Instituto de Cardiología, Bogotá, Colombia.
- 72 IRCCS San Raffaele Scientific Institute, Milan, Italy.
- 73 Careggi University Hospital, Florence, Italy.
- 74 A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
- 75 Sant'Andrea Hospital, Rome, Italy.
- 76 S. Maria della Misericordia University Hospital, Udine, Italy.
- 77 Serdang Hospital, Kajang, Malaysia.
- 78 Shifa International Hospital, Islamabad, Pakistan.
- 79 Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 80 Hospital Universitari Vall d'Hebron, Barcelona, Spain.
- 81 Hospital Universitari Sagrat Cor, Grupo Quironsalud, Barcelona, Spain.
- 82 Hospital Universitary Gregorio Marañon, Madrid, Spain.
- 83 Hospital del Mar, Barcelona, Spain.
- 84 Hospital Clínic, Barcelona, Barcelona, Spain.
- 85 Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
- 86 Department of Cardiothoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
- 87 The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
- 88 Atrium Health Wake Forest Baptist, Winston-Salem, NC, United States.
- 89 Cleveland Clinic Florida, Weston, FL, United States.
- 90 Henry Ford Health, Detroit, MI, United States.
- 91 Fairview Hospital, Cleveland Clinic, Cleveland, OH, United States.
- 92 Rhode Island Hospital, Providence, RI, United States.
- 93 The Ohio State University Wexner Medical Center, Columbus, OH, United States.
- 94 Stony Brook University Hospital, Stony Brook, NY, United States.
- PMID: 36754105
- DOI: 10.1016/j.ahj.2023.01.018
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Abstract
Background: Perioperative atrial fibrillation (AF) and myocardial injury after noncardiac surgery (MINS) are common complications after noncardiac surgery. Inflammation has been implicated in the pathogenesis of both disorders. The COP-AF trial tests the hypothesis that colchicine reduces the incidence of perioperative AF and MINS in patients undergoing major noncardiac thoracic surgery.
Methods and results: The 'COlchicine for the Prevention of Perioperative Atrial Fibrillation' (COP-AF) trial is an international, blinded, randomized trial that compares colchicine to placebo in patients aged at least 55 years and undergoing major noncardiac thoracic surgery with general anesthesia. Exclusion criteria include a history of AF and a contraindication to colchicine (eg, severe renal dysfunction). Oral colchicine at a dose of 0.5 mg or matching placebo is given within 4 hours before surgery. Thereafter, patients receive colchicine 0.5 mg or placebo twice daily for a total of 10 days. The 2 independent co-primary outcomes are clinically important perioperative AF (including atrial flutter) and MINS during 14 days of follow-up. The main safety outcomes are sepsis or infection and non-infectious diarrhea. We aim to enroll 3,200 patients from approximately 40 sites across 11 countries to have at least 80% power for the independent evaluation of the 2 co-primary outcomes. The COP-AF main results are expected in 2023.
Conclusions: COP-AF is a large randomized and blinded trial designed to determine whether colchicine reduces the risk of perioperative AF or MINS in patients who have major noncardiac thoracic surgery.
Keywords: Atrial fibrillation; Colchicine; Inflammation; Myocardial injury; Prevention; Thoracic surgery.
Copyright © 2023 Elsevier Inc. All rights reserved.
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