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Review
. 2023 Mar;52(1):65-88.
doi: 10.1016/j.ecl.2022.09.002.

Remission with an Intervention: Is Metabolic Surgery the Ultimate Solution?

Zubaidah Nor Hanipah  1 , Francesco Rubino  2 , Philip R Schauer  3
Affiliations
Review

Remission with an Intervention: Is Metabolic Surgery the Ultimate Solution?

Zubaidah Nor Hanipah et al. Endocrinol Metab Clin North Am. 2023 Mar.

Abstract

Long-term remission of type 2 diabetes following lifestyle intervention or pharmacotherapy, even in patients with mild disease, is rare. Long-term remission following metabolic surgery however, is common and occurs in 23% to 98% depending on disease severity and type of surgery. Remission after surgery is associated with excellent glycemic control without reliance on pharmacotherapy, improvements in quality of life, and major reductions in microvascular and macrovascular complications. For patients with type 2 diabetes, early intervention with metabolic surgery, when beta cell function still remains intact, provides the greatest probability of long-term remission as high as 90% or more.

Keywords: Bariatric surgery; Cardiovascular risk factor; Diabetes mellitus; Diabetes remission; Metabolic surgery; Type 2 diabetes; Weight loss.

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Conflict of interest statement

Disclosure Dr P.R. Schauer has the following relationships Consultancy Agreements: GI Dynamics; Keyron; Persona; Mediflix, Metabolic Health International, LTD, Novo Nordisk and Lilly Ownership Interest: SE Healthcare LLC, Mediflix, Metabolic Health International, LTD Research Funding: Ethicon; Medtronic; Pacira; Persona Honoraria: Ethicon; Medtronic; BD Surgical; Gore Scientific Advisor or Membership: SE Healthcare Board of Directors; GI Dynamics; Keyron; Persona; Mediflix. Dr Z.N. Hanipah has consultancy agreement with Novo Nordisk. Dr F. Rubino has the following relationships Research grants: Ethicon and Medtronic Consulting fees: Ethicon, Novo Nordisk, and Medtronic Scientific advisory board: GI Dynamics and Keyron.