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Comment
. 2023 Feb 8;43(6):879-881.
doi: 10.1523/JNEUROSCI.1994-22.2022.

Adult-Born Granule Cells Contribute to Dentate Gyrus Circuit Reorganization after Traumatic Brain Injury

Anne-Sophie Sack  1
Affiliations
Comment

Adult-Born Granule Cells Contribute to Dentate Gyrus Circuit Reorganization after Traumatic Brain Injury

Anne-Sophie Sack. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic of the main conclusions from Kang et al. (2022) illustrating a maturational stage-dependent contribution of GCs to feedback inhibition after CCI. Mature GCs that are born during the early postnatal period (P8-P12; early-born) show a moderate increase in their contribution to feedback inhibition (indicated with a dashed line) compared with similarly aged GCs in sham-injured mice. Whereas GCs that are immature at the time of injury (adult-born pre-CCI) show a substantial increase in feedback inhibition (thick line), GCs born after injury (adult-born post-CCI) have a limited contribution to feedback inhibition that is not different from what would be expected from this population under normal conditions (dotted line). Blue represents ChR2-expressing GC from each cohort. Red represents PV+ basket cell. Gray represents a ChR2-negative mature GC used for electrophysiological recordings.
See this image and copyright information in PMC

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