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Comment
. 2023 Mar;31(3):222-224.
doi: 10.1016/j.tim.2023.01.008. Epub 2023 Feb 6.

How to lose resistance to Aspergillus infections

Jean-Pierre Gangneux  1 , Martin Hoenigl  2 , Nicolas Papon  3
Affiliations
Free article
Comment

How to lose resistance to Aspergillus infections

Jean-Pierre Gangneux et al. Trends Microbiol. 2023 Mar.
Free article

Abstract

The distinct risk factors to deadly infections by Aspergillus fumigatus (Af) in intensive care unit (ICU) patients are well known; however, so far, the mechanistic link between these predisposing conditions has been unknown. Sarden et al. recently unraveled a shared B1a lymphocyte-natural antibody-neutrophil defense pathway to Af, opening new perspectives in diagnostics and therapeutics.

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Conflict of interest statement

Declaration of interests M.H. reports grants and research funding from Astellas, Gilead, MSD, Pfizer, Euroimmun, F2G, Pulmocide, IMMY, Mundipharma, and Scynexis. J-P.G. reports grants and research funding from Gilead, Pfizer, and Mundipharma.

Comment on

  • A B1a-natural IgG-neutrophil axis is impaired in viral- and steroid-associated aspergillosis.
    Sarden N, Sinha S, Potts KG, Pernet E, Hiroki CH, Hassanabad MF, Nguyen AP, Lou Y, Farias R, Winston BW, Bromley A, Snarr BD, Zucoloto AZ, Andonegui G, Muruve DA, McDonald B, Sheppard DC, Mahoney DJ, Divangahi M, Rosin N, Biernaskie J, Yipp BG. Sarden N, et al. Sci Transl Med. 2022 Dec 7;14(674):eabq6682. doi: 10.1126/scitranslmed.abq6682. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475902