Suppressing c-Abl in Parkinson disease

Comment

Sarah Crunkhorn. Nat Rev Drug Discov. 2023 Mar.

. 2023 Mar;22(3):183.

doi: 10.1038/d41573-023-00024-w.

No abstract available

Comment on

The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.
Karuppagounder SS, Wang H, Kelly T, Rush R, Nguyen R, Bisen S, Yamashita Y, Sloan N, Dang B, Sigmon A, Lee HW, Marino Lee S, Watkins L, Kim E, Brahmachari S, Kumar M, Werner MH, Dawson TM, Dawson VL. Karuppagounder SS, et al. Sci Transl Med. 2023 Jan 18;15(679):eabp9352. doi: 10.1126/scitranslmed.abp9352. Epub 2023 Jan 18. Sci Transl Med. 2023. PMID: 36652533

1. Karuppagounder, S. et al. The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson’s disease. Sci. Transl Med. 15, eabp9352 (2023) - PubMed - DOI