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. 2022 Dec 22;17(1):45-54.
doi: 10.21010/Ajidv17i1.4. eCollection 2023.

CORRELATION OF SARS-COV-2 EXPRESSION IN THE PLACENTA AND THE INCIDENCE OF PREECLAMPSIA

Lumbanraja Sarma  1 , Effendi Iman Helmy  1 , Siahaan Andre M  2 , Bancin Berry E P  1 , Edianto Deri  1 , Asroel Edwin Martin  1 , Sudewo Yudha  1
Affiliations

CORRELATION OF SARS-COV-2 EXPRESSION IN THE PLACENTA AND THE INCIDENCE OF PREECLAMPSIA

Lumbanraja Sarma et al. Afr J Infect Dis. .

Abstract

Background: The pandemic caused by SARS-CoV-2 also caused infection in some pregnant women. Some reports say this viral infection can show symptoms of preeclampsia.

Material and methods: We analyzed 25 pregnant women with SARS-CoV-2 infection with 4 patients presenting with symptoms of preeclampsia. we performed routine blood analysis, renal function, liver function, and IHC examination to see the expression of viral proteins in the placenta.

Results: we obtained 4 patients with confirmed SARS-CoV-2 infection by RT-PCR. In these 4 cases, none of the cases showed expression of the SARS-CoV-2 viral protein in the placenta, and all 4 mothers were declared dead after treatment, and 2 babies delivered out of these 4 cases died. In one case we had fetal death in pregnancy while in one case prematurity. 2 babies born to mothers with SARS-CoV-2 infection with preeclampsia were born in good condition. There were no babies infected with SARS-CoV-2.

Conclusion: We conclude that SAR-CoV-2 infection in pregnant women with comorbidities can lead to a poor prognosis for both mother and baby. We cannot yet conclude whether SARS-CoV-2 infection can cause preeclampsia, but SARS-CoV-2 infection can exacerbate preeclampsia symptoms.

Keywords: Histopathology; IHC; Nucleocapsid; Preeclampsia; SAR-CoV-2.

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Figures

Figure 1
Figure 1
Intensity and Proportion Scores.
Figure 2
Figure 2
(a) Positive control of IHK rabbit antibody-antigen SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] in lung tissue of patients with RT-PCR confirmed COVID-19 infection (400x magnification); (b) Histopathology of placental tissue with hematoxylin and eosin staining (400x magnification); (c) Histopathology of placental tissue from patients with RT-PCR confirmed COVID-19 infection, positive CPI (400x magnification); (d) Histopathology of placental tissue from patients with RT-PCR confirmed COVID-19 infection, negative CPI (400x magnification).
See this image and copyright information in PMC

References

    1. Baergen R. N, Heller D. S. Placental Pathology in Covid-19 Positive Mothers:Preliminary Findings. Pediatric and Developmental Pathology. 2020;23(3):177–180. https://doi.org/10.1177/1093526620925569. - PMC - PubMed
    1. Breslin N, Baptiste C, Miller R, Fuchs K, Goffman D, Gyamfi-Bannerman C, D'Alton M. Coronavirus disease 2019 in pregnancy:Early lessons. American Journal of Obstetrics and Gynecology MFM. 2020;2(2):100111. https://doi.org/10.1016/j.ajogmf.2020.100111. - PMC - PubMed
    1. Cao D, Yin H, Chen J, Tang F, Peng M, Li R, Xie H, Wei X, Zhao Y, Sun G. Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China:A retrospective study. International Journal of Infectious Diseases. 2020;95:294–300. https://doi.org/10.1016/j.ijid.2020.04.047. - PMC - PubMed
    1. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women:A retrospective review of medical records. 2020;395:8. - PMC - PubMed
    1. Fahmi A, Brügger M, Démoulins T, Zumkehr B, Oliveira Esteves B. I, Bracher L, Wotzkow C, Blank F, Thiel V, Baud D, Alves M. P. SARS-CoV-2 can infect and propagate in human placenta explants. Cell Reports Medicine. 2021;2(12):100456. https://doi.org/10.1016/j.xcrm.2021.100456. - PMC - PubMed

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