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Review
. 2023 Mar 15;81(1):7-23.
doi: 10.1684/abc.2023.1782.

[Immuno-analytical characteristics of PSA and derived biomarkers (total PSA, free PSA, p2PSA)]

[Article in French]
Cédric Desbène  1 , Mathieu Boissan  2 , Sylvain Loric  3 , Pierre-Jean Lamy  4 , Laurence Piéroni  1
Affiliations
Review

[Immuno-analytical characteristics of PSA and derived biomarkers (total PSA, free PSA, p2PSA)]

[Article in French]
Cédric Desbène et al. Ann Biol Clin (Paris). .

Abstract

Prostate-specific antigen (PSA) is the recommended tumor marker for individual screening and follow-up of prostate cancer. This paper reviews main structural and physiological data about prostate specific antigen isoforms: total PSA, free PSA, [-2]proPSA (also named p2PSA). It describes the pre-, per- and post-analytical conditions for these different parameters. It presents the interpretation of results and derived calculated indices (free/total PSA ratio, Prostate Health Index or PHI) for the management of prostate cancer (initial diagnosis and follow-up).

Keywords: [-2]proPSA; free PSA; prostate cancer; prostate specific antigen; total PSA; tumor markers.

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