Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun;31(3):1095-1105.
doi: 10.1007/s10787-023-01140-0. Epub 2023 Feb 9.

A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease

Hossein Shahdadi Sardou  1   2 , Paria Rahnama Vosough  3 , Mohammadreza Abbaspour  1   2 , Abbas Akhgari  1   2 , Thozhukat Sathyapalan  4 , Amirhossein Sahebkar  5   6   7
Affiliations
Review

A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease

Hossein Shahdadi Sardou et al. Inflammopharmacology. 2023 Jun.

Abstract

Synthetic drugs and monoclonal antibodies are the typical treatments to combat inflammatory bowel disease (IBD). However, side effects are present when these treatments are used, and their continued application could be restricted by the high relapse rate of the disease. One potential alternative to these treatments is the use of plant-derived products. The use curcumin is one such treatment option that has seen an increase in usage in treating IBD. Curcumin is derived from a rhizome of turmeric (Curcuma longa), and the results of studies on the use of curcumin to treat IBD are promising. These studies suggest that curcumin interacts with cellular targets such as NF-κB, JAKs/STATs, MAPKs, TNF-α, IL-6, PPAR, and TRPV1 and may reduce the progression of IBD. Potentially, curcumin can be used as a therapeutic agent for patients with IBD when it reduces the incidence of clinical relapse. This review discusses the strategies utilized in designing and developing an oral colonic delivery dosage form of curcumin.

Keywords: Colon delivery; Curcumin; Gastrointestinal tract; IBD; Microparticles; Nanoparticles.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abdollahi E, Momtazi AA, Johnston TP, Sahebkar A (2018) Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: a nature-made Jack-of-all-trades? J Cell Physiol 233(2):830–848 - PubMed - DOI
    1. Agagunduz D, Sahin TO, Yilmaz B, Ekenci KD, Duyar Ozer S, Capasso R (2022) Cruciferous vegetables and their bioactive metabolites: from prevention to novel therapies of colorectal cancer. Evid Based Complement Alternat Med 2022:1534083. https://doi.org/10.1155/2022/1534083 - DOI - PubMed - PMC
    1. Ahir AA, Mali SS, Hajare AA, Bhagwat DA, Patrekar PV (2015) Pelletization technology: methods and applications-a review. Res J Pharm Technol 8(2):131 - DOI
    1. Akkol EK, Karpuz B, Sobarzo-Sánchez E, Khan H (2020) A phytopharmacological overview of medicinal plants used for prophylactic and treatment of colitis. Food Chem Toxicol 144:111628 - PubMed - DOI
    1. Alidadi M, Jamialahmadi T, Cicero AFG, Bianconi V, Pirro M, Banach M et al (2020) The potential role of plant-derived natural products in improving arterial stiffness: a review of dietary intervention studies. Trends Food Sci Technol 99:426–440. https://doi.org/10.1016/j.tifs.2020.03.026 - DOI