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. 2023 Jul;53(7):753-761.
doi: 10.1007/s00595-023-02643-7. Epub 2023 Feb 9.

Examination of colorectal cancer cases with metal allergy

Kosuke Mizukoshi  1   2 , Yu Okazawa  3 , Kota Amemiya  3 , Yuki Tsuchiya  3 , Shunsuke Motegi  3 , Ryoichi Tsukamoto  3 , Kumpei Honjo  3 , Rina Takahashi  3 , Nagisa Yoshihara  4 , Shingo Kawano  3 , Masaya Kawai  3 , Shinya Munakata  3 , Shun Ishiyama  3 , Kiichi Sugimoto  3 , Makoto Takahashi  3 , Yutaka Kojima  3 , Shigaku Ikeda  4 , Kazuhiro Sakamoto  3
Affiliations

Examination of colorectal cancer cases with metal allergy

Kosuke Mizukoshi et al. Surg Today. 2023 Jul.

Abstract

Purpose: To report our initiatives and treatment results for patients with colorectal cancer with metal allergy.

Methods: A total of 27 patients (2.6%) with a history of metal contact dermatitis were identified among 1027 patients who underwent curative resection of colorectal cancer from 2014 to 2020. The results of the patch test, perioperative results, and postoperative colonoscopy findings were also investigated.

Results: The patch test for metal allergens and staples was performed in 21 patients (77.8%), and 13 of them (61.9%) tested positive for at least one metal allergen. Ni (38.1%), Co (28.6%), and Pd (19.0%) showed higher positive rates than other metals, and 1 patient (4.8%) tested positive for staples. Stapled anastomosis/suturing was performed as planned in 15 of 27 patients. In 10 patients, the anastomosis method was changed from stapled to hand-sewn according to the no-patch test results (60%), positivity for multiple metals (20%), positivity for staples (10%), and surgeon's judgment (10%). No complications and abnormal colonoscopy findings were found to be associated with stapled anastomosis/suturing.

Conclusion: The patch test is useful for selecting an optimal anastomosis method for patients with suspected metal allergy.

Keywords: Colorectal cancer; Metal allergy; Patch test; Stapled anastomosis.

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