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Review
. 2023 Jan 24:10:1094188.
doi: 10.3389/fcvm.2023.1094188. eCollection 2023.

Glycation of LDL: AGEs, impact on lipoprotein function, and involvement in atherosclerosis

Anastasia V Poznyak  1 , Vasily N Sukhorukov  2 , Raisa Surkova  2 , Nikolay A Orekhov  2 , Alexander N Orekhov  1   2
Affiliations
Review

Glycation of LDL: AGEs, impact on lipoprotein function, and involvement in atherosclerosis

Anastasia V Poznyak et al. Front Cardiovasc Med. .

Abstract

Atherosclerosis is a complex disease, and there are many factors that influence its development and the course of the disease. A deep understanding of the pathological mechanisms underlying atherogenesis is needed to develop optimal therapeutic strategies and treatments. In this review, we have focused on low density lipoproteins. According to multiple studies, their atherogenic properties are associated with multiple modifications of lipid particles. One of these modifications is Glycation. We considered aspects related to the formation of modified particles, as well as the influence of modification on their functioning. We paid special attention to atherogenicity and the role of glycated low-density lipoprotein (LDL) in atherosclerosis.

Keywords: AGE; LDL; LDL modification; atherosclerosis; glycation; lipids.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
In the blood flow, low-density lipoprotein (LDL) undergoes multiple modifications and acquires atherogenic properties. Modified LDL particles have a tendency to form self-associates that, in turn, promote phagocytosis of subendothelial arterial cells. Being triggered by phagocytosis, proinflammatory response emerges and pro-inflammatory cytokines are secreted. Pro-inflammatory cytokines promote or even cause the accumulation of intracellular lipids, which leads to the formation of foam cells (From 52).
See this image and copyright information in PMC

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