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. 2023 Jan 9;25(2):93.
doi: 10.3892/etm.2023.11792. eCollection 2023 Feb.

Clinical and pathological studies of eight cases of lipidized fibrous histiocytoma

Fangyun Liu  1 , Hongjun Wang  2 , Guoying Wu  3 , Congyang Li  3
Affiliations

Clinical and pathological studies of eight cases of lipidized fibrous histiocytoma

Fangyun Liu et al. Exp Ther Med. .

Abstract

Lipidized fibrous histiocytoma (FH) is a rare type of FH. The present study aimed to describe the clinical and pathological features of lipidized FH. A total of eight patients diagnosed with lipidized FH were retrospectively reviewed in the present study. The cohort included three male and five female patients (male to female ratio, 1.7:1) with a mean age of 48 years (range, 38-62 years). In total, four tumors were located on the buttock, three on the lower leg and one on the forearm. Histological, lipidized FH showed a wide spectrum. Some cases included prominent stromal hyalinization and hyalinized vessels with scant lipid-laden histiocytes. Other cases exhibited the prominent lipid-laden histiocytes and scant stromal hyalinization. Overall, lipidized FH must be differentiated from other benign and malignant tumors, taking into account the therapeutic and prognostic differences between these different entities.

Keywords: dermatofibroma; fibrous histiocytoma; lipidized fibrous histiocytoma.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Following sectioning, the tumor was yellow in color and mixed with white in patient 2.
Figure 2
Figure 2
Patient 2. (A) A well-circumscribed lesion located at the dermis (magnification, x1). The epidermis exhibited hyperplasia and irregular elongation of the rete ridge (black arrow). (B) Fibroblasts arranged in a storiform pattern (magnification, x7). (C) Fibroblasts arranged in a storiform pattern, and hyalinized collagen fibers transmigrated with normal collagen fibers (magnification, x9). (D) Histiocytes were oval to polygonal in shape with large hypochromatic nuclei, prominent nucleoli and abundantly vacuolated cytoplasm (blue arrow). The fibroblasts exhibited no cytologic atypia, with elongated nuclei, fine chromatin and small basophilic nucleoli (green arrow). (E) Prominent hyalinized vessels were documented (magnification, x40). (F) The histiocytes were strongly positive for CD68 (4+, magnification, x40).
Figure 3
Figure 3
Patient 5. (A) A well-circumscribed lesion located at the dermis (magnification, x0.64). The epidermis exhibited hyperplasia and irregular elongation of the rete ridge (black arrow). (B) Fibroblasts arranged in a storiform pattern (magnification, x4). (C) Prominent hyalinized collagen fibers (magnification, x20). Histiocytes were oval to polygonal in shape with large hypochromatic nuclei, prominent nucleoli and abundantly vacuolated cytoplasm (blue arrow). The fibroblasts exhibited no cytologic atypia, with elongated nuclei, fine chromatin and small basophilic nucleoli (green arrow). (D) Multinucleated Touton-type giant cells (magnification, x20).
Figure 4
Figure 4
Patient 8. (A) A well-circumscribed lesion located at the dermis (magnification, x1). (B) Fibroblasts arranged in a storiform pattern (magnification, x5). (C) Prominent hyalinized collagen fibers (magnification, x18). Histiocytes were oval to polygonal in shape with large hypochromatic nuclei, prominent nucleoli and abundantly vacuolated cytoplasm (blue arrow). The fibroblasts exhibited no cytologic atypia, with elongated nuclei, fine chromatin and small basophilic nucleoli (green arrow). (D) The histiocytes were strongly positive for CD68 (4+, magnification, x40).
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