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. 2023 Jan 25:14:1124027.
doi: 10.3389/fendo.2023.1124027. eCollection 2023.

Nanomaterials for diabetic wound healing: Visualization and bibliometric analysis from 2011 to 2021

Jun Zhang  1 , Hongyan Liu  1 , Tingting Che  1 , Yin Zheng  2 , Xixi Nan  2 , Zhongming Wu  1   2
Affiliations

Nanomaterials for diabetic wound healing: Visualization and bibliometric analysis from 2011 to 2021

Jun Zhang et al. Front Endocrinol (Lausanne). .

Abstract

Background: Nanomaterials have recently been shown to have a considerable advantage in promoting wound healing in diabetic patients or animal models. However, no bibliometric analysis has been conducted to evaluate global scientific production. Herein, this study aimed to summarize the current characteristics, explore research trends, and clarify the direction of nanomaterials and diabetic wound healing in the future.

Methods: Relevant publications from 2011 to 2021 were collected from the Web of Science Core Collection on October 3, 2022. VOSviewer, CiteSpace, bibliometrix-R package, Origin 2021, and Microsoft Excel 2019 were used for bibliometric and visualization analyses.

Results: We identified 409 publications relating to nanomaterials and diabetic wound healing. The number of annual productions remarkably increased from 2011 to 2021, with China and Shanghai Jiao Tong University being the most productive. The most prolific authors were Hasan Anwarul. The leading journal was the International Journal of Biological Macromolecules, with 22 publications. The most popular keywords were "nanoparticles," "delivery," "in vitro," "electrospinning," "angiogenesis," and "antibacterial." Keyword burst analysis showed "cerium oxide," "matrix metalloproteinase 9," "composite nanofiber," "hif 1 alpha," and "oxide nanoparticle" were emerging research hotspots.

Conclusion: We found there has been a great progress in the application of nanomaterials in diabetic wound healing from 2011 to 2021. Although many researchers and institutions from different countries or regions contributed contributed to publications, it will be helpful or the development of this field if the degree of international cooperation can be enhanced. In the future, nanomaterials with powerful antioxidant and antibacterial qualities and promoting angiogenesis are the research hotspots.

Keywords: bibliometric; diabetic non-healing wound; knowledge map; research trends; web of science.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart for including and excluding publications.
Figure 2
Figure 2
Annual number of publications (A) and theme clusters for the nanomaterials in diabetic non-healing wound by Carrot2 (B).
Figure 3
Figure 3
Map of global publications.
Figure 4
Figure 4
The distribution of single or multiple country papers in top 10 countries (A); annual number of publications in China, India and USA (B); The international cooperation networks between countries/regions (C); VOSviewer network map of countries/regions (D).
Figure 5
Figure 5
VOSviewer network map of institutions (A); Density distribution map of institutions (B). Minimum number of articles published by the institution was set to 5.
Figure 6
Figure 6
VOSviewer network map of authors (A); Density distribution map of authors (B).
Figure 7
Figure 7
The dual-map overlay of journals contributed to publications regarding nanomaterials for diabetic wound healing from 2011 to 2021.
Figure 8
Figure 8
Word cloud of top 50 plus keywords (A); Word cloud of top 50 author’s keywords (B); Map of keyword clusters (C); Timeline view of keyword co-occurrence (D).
Figure 9
Figure 9
Top 30 keywords with the strongest citation bursts.
Figure 10
Figure 10
Map of cited references clusters (A); Timeline view of cited references co-occurrence (B); Top 18 references with the strongest citation bursts (C).
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