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. 2023 Jan 31:2023:7571696.
doi: 10.1155/2023/7571696. eCollection 2023.

Circulating miR-340-5p and miR-506-3p as Two Osteo-miRNAs for Predicting Osteoporosis in a Cohort of Postmenopausal Women

Zifeng Lu  1 , Haiou Cao  2 , Xiaoyin Hu  3
Affiliations

Circulating miR-340-5p and miR-506-3p as Two Osteo-miRNAs for Predicting Osteoporosis in a Cohort of Postmenopausal Women

Zifeng Lu et al. J Environ Public Health. .

Retraction in

Abstract

Objective: An increasing risk of developing osteoporosis which is characterized by bone production weakness and microarchitectural deterioration is found among postmenopausal women. MicroRNAs (miRNAs) are secreted into the circulation from cells of various tissues in response to local disease severity including bone diseases. Herein, we set out to identify candidate miRNAs predictable for osteoporosis incidence in postmenopausal elderly women.

Methods: The circulating miRNA expression profiles deposited in the dataset accessioned as GSE201543 were downloaded from the GEO database. The study included 176 postmenopausal women who underwent BMD testing, including 96 women reporting osteoporosis and 70 women reporting normal BMD. All subjects were submitted their serum samples for measurements of bone metabolism markers.

Results: The miRNA expression profiles of the GSE201543 dataset were differentially analyzed and found 97 miRNAs being upregulated concomitantly with 31 miRNAs being downregulated in the serum samples between osteoporotic postmenopausal women and postmenopausal women with normal BMD. Osteoporotic postmenopausal women were demonstrated with elevated serum levels of miR-340-5p and miR-506-3p when compared to normal postmenopausal women. Pearson correlation analysis demonstrated that circulating miR-340-5p and miR-506-3p expressions were increased as BAP, β-CTx, and PINP levels increased, but osteocalcin and 25-(OH)VitD levels are declined in osteoporotic postmenopausal women. Results of the receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) showed circulating miR-340-5p and miR-506-3p expressions alone or combined together produced 0.843 AUC, 0.851 AUC, and 0.935 AUC, respectively, when used to predict the incidence of osteoporosis in postmenopausal women.

Conclusion: Our work suggested that circulating miR-340-5p and miR-506-3p function as osteo-miRNAs in postmenopausal women and may serve as potential noninvasive biomarkers for the incidence of osteoporosis in postmenopausal women.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The serum levels of baseline bone parameters between osteoporotic postmenopausal women (n = 96) and postmenopausal women with normal BMD (n = 70). ∗p < 0.05, compared with postmenopausal women with normal BMD (by the unpaired t-test).
Figure 2
Figure 2
Circulating miR-340-5p and miR-506-3p expressions in clinical samples between osteoporotic postmenopausal women (n = 96) and postmenopausal women with normal BMD (n = 70). ∗p < 0.05, compared with postmenopausal women with normal BMD (by the unpaired t-test).
Figure 3
Figure 3
Correlation analysis between circulating miR-340-5p, miR-506-3p, and bone metabolism markers in osteoporotic postmenopausal women (n = 96).
Figure 4
Figure 4
The diagnostic values of circulating miR-340-5p (a) and miR-506-3p (b) alone or combined together (c) in osteoporotic postmenopausal women (n = 96).
See this image and copyright information in PMC

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