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Review
. 2023 Jan 18;18(2):13.
doi: 10.3892/mco.2023.2609. eCollection 2023 Feb.

Circulating cervical cancer biomarkers potentially useful in medical attention (Review)

Ruth Ruiz Esparza Garrido  1 , Mercedes Gutiérrez  2 , Miguel Ángel Velázquez Flores  3
Affiliations
Review

Circulating cervical cancer biomarkers potentially useful in medical attention (Review)

Ruth Ruiz Esparza Garrido et al. Mol Clin Oncol. .

Abstract

Cervical cancer (CC) is a public health problem worldwide, including Mexico. This type of cancer is the fourth most frequent in women worldwide; in Mexico it is the second most common type in women after breast cancer. The diagnosis of CC is based mainly on Pap smears and colposcopy and the identification of molecular tools that serve as a support for these methods is urgent. Regarding this, differential expressions of specific circulating biomolecules has been detected and, based on this, they have been postulated as potential biomarkers for CC diagnosis, prognosis, and/or to identify the response to treatments. Importantly, the combined analysis of these molecules considerably improves their efficacy as biomarkers and their potential use in the medical attention is promising.

Keywords: cervical cancer; circulating biomarker; diagnosis; prognosis; response to treatments.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Upregulated miRNAs. These group of miRNAs have the potential to be biomarkers to distinguish CIN, LGCLs or CC from the controls. MiRs 18 and 17-5p showed the highest sensitivity for CC diagnosis (˜95%). LGCLs, low-grade cervical lesions; CIN, cervical intraepithelial lesions; CC, cervical cancer; miRNA or miR, microRNA.
Figure 2
Figure 2
Downregulated miRNAs. miR-651 showed the highest AUC value to detect CC and it was also positively correlated with cisplatin resistance. Meanwhile, miR-638 had a very high sensitivity for CSSC diagnosis, but only when its expression was analyzed with that of SCC. miRNA or miR, microRNA; AUC, area under the curve; CC, cervical cancer; CSCC, cervical squamous cell carcinoma.
Figure 3
Figure 3
Combined miRNAs analysis. The combined analysis of the miRNAs expression showed their potential use to diagnose CIN and CC, as well as to CC prognosis and to determine the response to treatments of patients. Importantly, the combination of two or more miRNAs considerably increases the sensitivity and specificity to detect and/or predict the response of patients to treatments. miRNA or miR, microRNA; CIN, cervical intraepithelial lesions; CC, cervical cancer; AUC, area under the curve.
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