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Review
. 2023 Jan 25:12:1101823.
doi: 10.3389/fonc.2022.1101823. eCollection 2022.

Exosomes as drug delivery system in gastrointestinal cancer

Fangyuan Xie  1 , Yueying Huang  1 , Yangyang Zhan  1 , Leilei Bao  1
Affiliations
Review

Exosomes as drug delivery system in gastrointestinal cancer

Fangyuan Xie et al. Front Oncol. .

Abstract

Gastrointestinal cancer is one of the most common malignancies with relatively high morbidity and mortality. Exosomes are nanosized extracellular vesicles derived from most cells and widely distributed in body fluids. They are natural endogenous nanocarriers with low immunogenicity, high biocompatibility, and natural targeting, and can transport lipids, proteins, DNA, and RNA. Exosomes contain DNA, RNA, proteins, lipids, and other bioactive components, which can play a role in information transmission and regulation of cellular physiological and pathological processes during the progression of gastrointestinal cancer. In this paper, the role of exosomes in gastrointestinal cancers is briefly reviewed, with emphasis on the application of exosomes as drug delivery systems for gastrointestinal cancers. Finally, the challenges faced by exosome-based drug delivery systems are discussed.

Keywords: cancer therapy; drug delivery system; exosomes; extracellular vesicles; gastrointestinal cancer.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewers WL and JH declared a shared parent affiliation, with no collaboration, with the authors to the handling editor at the time of the review.

Figures

Figure 1
Figure 1
The role of exosomes in gastrointestinal cancers.
See this image and copyright information in PMC

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