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Review
. 2023 Jan 24:14:1116548.
doi: 10.3389/fimmu.2023.1116548. eCollection 2023.

Skin-associated adipocytes in skin barrier immunity: A mini-review

Jingyan Guan  1 , Congxiao Wu  1 , Yunfan He  1 , Feng Lu  1
Affiliations
Review

Skin-associated adipocytes in skin barrier immunity: A mini-review

Jingyan Guan et al. Front Immunol. .

Abstract

The skin contributes critically to health via its role as a barrier tissue against a multitude of external pathogens. The barrier function of the skin largely depends on the uppermost epidermal layer which is reinforced by skin barrier immunity. The integrity and effectiveness of skin barrier immunity strongly depends on the close interplay and communication between immune cells and the skin environment. Skin-associated adipocytes have been recognized to play a significant role in modulating skin immune responses and infection by secreting cytokines, adipokines, and antimicrobial peptides. This review summarizes the recent understanding of the interactions between skin-associated adipocytes and other skin cells in maintaining the integrity and effectiveness of skin barrier immunity.

Keywords: adipocytes; adipokines; antimicrobial peptides; infection; skin barrier immunity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Diagrammatic representation of the effects of skin-associated adipocytes on skin barrier immunity (Created with BioRender.com. Agreement NO. QN24VPBCG8).
See this image and copyright information in PMC

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