Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 24:13:1071770.
doi: 10.3389/fonc.2023.1071770. eCollection 2023.

Geographic variation in malignant cardiac tumors and their outcomes: SEER database analysis

Mohamed Rahouma  1   2 , Sherif Khairallah  1   2 , Anas Dabsha  1   2 , Massimo Baudo  1   3 , Magdy M El-Sayed Ahmed  4   5 , Ivancarmine Gambardella  1 , Christopher Lau  1 , Yomna M Esmail  1 , Abdelrahman Mohamed  2 , Leonard Girardi  1 , Mario Gaudino  1 , Roberto Lorusso  6   7 , Stephanie L Mick  1
Affiliations

Geographic variation in malignant cardiac tumors and their outcomes: SEER database analysis

Mohamed Rahouma et al. Front Oncol. .

Abstract

Introduction: Primary malignant cardiac tumors (PMCTs) are rare. Geographical distribution has been demonstrated to affect cancer outcomes, making the reduction of geographical inequalities a major priority for cancer control agencies. Geographic survival disparities have not been reported previously for PMCT and the aim of this study is to compare the prevalence and the long-term survival rate with respect to the geographic location of PMCTs using the Surveillance, Epidemiology, and End Results (SEER) research plus data 17 registries between 2000 and 2019.

Methods: The SEER database was queried to identify geographic variation among PMCTs. We classified the included states into 4 geographical regions (Midwest, Northeast, South and West regions) based on the U.S. Census Bureau-designated regions and divisions. Different demographic and clinical variables were analyzed and compared between the four groups. Kaplan Meier curves and Cox regression were used for survival assessment.

Results: A total of 563 patients were included in our analysis. The median age was 53 years (inter-quartile range (IQR): 38 - 68 years) and included 26, 90, 101, and 346 patients from the Midwest, Northeast, South, and West regions respectively. Sarcoma represented 65.6% of the cases, followed by hematological tumors (26.2%), while mesothelioma accounted for 2.1%. Treatment analysis showed no significant differences between different regions. Median overall survival was 11, 21, 13, and 11 months for Midwest, Northeast, South and West regions respectively and 5-year overall survival was 22.2%, 25.4%, 14.9%, and 17.6% respectively. On multivariate Cox regression, significant independent predictors of late overall mortality among the entire cohort included age (Hazard Ratio [HR] 1.028), year of diagnosis (HR 0.967), sarcoma (HR 3.36), surgery (HR 0.63) and chemotherapy (HR 0.56).

Conclusion: Primary malignant cardiac tumors are rare and associated with poor prognosis. Sarcoma is the most common pathological type. Younger age, recent era diagnosis, surgical resection, and chemotherapy were the independent predictors of better survival. While univariate analysis revealed that patients in the South areas had a worse survival trend compared to other areas, geographic disparity in survival was nullified in multivariate analysis.

Keywords: cardiac surgery; database analysis; geographic variation; oncology; primary malignant cardiac tumors.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Kaplan Meier curve of overall survival (OS) (A) and cancer specific survival (CSS) (B) among different geographic areas.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Oliveira GH, Al-Kindi SG, Hoimes C, Park SJ. Characteristics and survival of malignant cardiac tumors: a 40-year analysis of> 500 patients. Circulation (2015) 132(25):2395–402. doi: 10.1161/CIRCULATIONAHA.115.016418 - DOI - PubMed
    1. Realdo C. De re anatomica. Venice: Nicolae Beuil-acquae [Facsimile Culture et Civilisation, Bruxelles; (1969).
    1. Simpson L, Kumar SK, Okuno SH, Schaff HV, Porrata LF, Buckner JC, et al. . Malignant primary cardiac tumors: review of a single institution experience. Canc: Interdiscip Int J Am Cancer Soc (2008) 112(11):2440–6. doi: 10.1002/cncr.23459 - DOI - PubMed
    1. Barnes AR, Beaver DC, Snell AM. Primary sarcoma of the heart: report of a case with electrocardiographic and pathological studies. Am Heart J (1934) 9(4):480–91. doi: 10.1016/S0002-8703(34)90096-X - DOI
    1. Cresti A, Chiavarelli M, Glauber M, Tanganelli P, Scalese M, Cesareo F, et al. . Incidence rate of primary cardiac tumors: a 14-year population study. J Cardiovasc Med (2016) 17(1):37–43. doi: 10.2459/JCM.0000000000000059 - DOI - PubMed

LinkOut - more resources