doi: 10.1016/0005-2736(87)90005-8.
The mechanism of liposomal damage by taurocholate
Affiliations
- PMID: 3676312
- DOI: 10.1016/0005-2736(87)90005-8
Item in Clipboard
The mechanism of liposomal damage by taurocholate
Biochim Biophys Acta.
.
Abstract
The stability of small unilamellar vesicles formed by egg-yolk phosphatidylcholine (PC) has been examined in the presence of sodium taurocholate. The permeability of the vesicular membrane changes as the total taurocholate concentration increases, until a transformation from mixed bile salt/PC vesicles to mixed micelles occurs. Based on experiments in which the bile salt-induced release of either hydrophilic (carboxyfluorescein) or hydrophobic (Bromothymol blue) probes was studied, and on fluorescence polarization of the probe 1,6-diphenyl-1,3,5-hexatriene and turbidity measurements, a two-step process for the initial stage of liposomal damage by taurocholate is postulated.
Similar articles
-
Activity of bile-salt-stimulated human milk lipase in the presence of liposomes and mixed taurocholate-phosphatidylcholine micelles.Biochim Biophys Acta. 1987 Nov 27;905(1):39-47. doi: 10.1016/0005-2736(87)90006-x. Biochim Biophys Acta. 1987. PMID: 3676313
-
Asymmetric distribution of phosphatidylcholine and sphingomyelin between micellar and vesicular phases. Potential implications for canalicular bile formation.J Lipid Res. 1999 Nov;40(11):2022-33. J Lipid Res. 1999. PMID: 10553006
-
Incorporation of cholesterol in sphingomyelin- phosphatidylcholine vesicles has profound effects on detergent-induced phase transitions.J Lipid Res. 2002 Jul;43(7):1046-53. doi: 10.1194/jlr.m100355-jlr200. J Lipid Res. 2002. PMID: 12091488
-
Insertion and partition of sodium taurocholate into egg phosphatidylcholine vesicles.Pharm Res. 2004 Aug;21(8):1505-16. doi: 10.1023/b:pham.0000036927.37888.93. Pharm Res. 2004. PMID: 15359588
-
Separation and quantitation of cholesterol "carriers" in bile.Hepatology. 1990 Sep;12(3 Pt 2):94S-104S; discussion 104S-105S. Hepatology. 1990. PMID: 2210665 Review.
Cited by
-
Bolalipid-Doped Liposomes: Can Bolalipids Increase the Integrity of Liposomes Exposed to Gastrointestinal Fluids?Pharmaceutics. 2019 Dec 3;11(12):646. doi: 10.3390/pharmaceutics11120646. Pharmaceutics. 2019. PMID: 31816937 Free PMC article.
-
Interactions between organic anions, micelles and vesicles in model bile systems.Biochem J. 1996 Dec 15;320 ( Pt 3)(Pt 3):917-23. doi: 10.1042/bj3200917. Biochem J. 1996. PMID: 9003381 Free PMC article.
-
Cefotaxime pharmacokinetics after oral application in the form of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate microvesicles in rat.Eur J Drug Metab Pharmacokinet. 2009 Jan-Mar;34(1):31-6. doi: 10.1007/BF03191381. Eur J Drug Metab Pharmacokinet. 2009. PMID: 19462926
-
Development and characterization of lactoferrin nanoliposome: cellular uptake and stability.Nanoscale Res Lett. 2012 Dec 17;7(1):679. doi: 10.1186/1556-276X-7-679. Nanoscale Res Lett. 2012. PMID: 23244160 Free PMC article.
-
Optimization of Conditions for Cyanidin-3-OGlucoside (C3G) Nanoliposome Production by Response Surface Methodology and Cellular Uptake Studies in Caco-2 Cells.Molecules. 2017 Mar 13;22(3):457. doi: 10.3390/molecules22030457. Molecules. 2017. PMID: 28335396 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
