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. 1987 Nov 21;922(2):234-8.
doi: 10.1016/0005-2760(87)90159-7.

X-ray diffraction study of cholesterol-phosphatidylserine mixtures

E J Wachtel  1 , D Bach
Affiliations

X-ray diffraction study of cholesterol-phosphatidylserine mixtures

E J Wachtel et al. Biochim Biophys Acta. .

Abstract

Phosphatidylserine-cholesterol mixtures at a molar ratio of 2:1 were investigated by X-ray diffraction. Phase separation of cholesterol independent of temperature was detected, indicating limited solubility of cholesterol in phosphatidylserine bilayers. The second phase present, the mixed phospholipid-cholesterol phase, continued to undergo melting as determined by changes with temperature in both the small angle scattering profile and in the acyl chain packing.

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