X-ray diffraction study of cholesterol-phosphatidylserine mixtures
- PMID: 3676345
- DOI: 10.1016/0005-2760(87)90159-7
X-ray diffraction study of cholesterol-phosphatidylserine mixtures
Abstract
Phosphatidylserine-cholesterol mixtures at a molar ratio of 2:1 were investigated by X-ray diffraction. Phase separation of cholesterol independent of temperature was detected, indicating limited solubility of cholesterol in phosphatidylserine bilayers. The second phase present, the mixed phospholipid-cholesterol phase, continued to undergo melting as determined by changes with temperature in both the small angle scattering profile and in the acyl chain packing.
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