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. 2023 Apr:109:105407.
doi: 10.1016/j.meegid.2023.105407. Epub 2023 Feb 9.

Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon

Luciano Chaves Franco Filho  1 , Rafael Ribeiro Barata  2 , Mônica Silva Coelho  3 , Jedson Ferreira Cardoso  2 , Poliana da Silva Lemos  4 , Herald Souza Dos Reis  2 , Joana da Felicidade Ribeiro Favacho  2 , Nuno Rodrigues Faria  5 , Marcio Roberto Teixeira Nunes  2
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Free article

Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon

Luciano Chaves Franco Filho et al. Infect Genet Evol. 2023 Apr.
Free article

Abstract

The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the region.

Keywords: Arboviruses; Chiroptera; Dengue virus; High-throughput nucleotide sequencing.

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Conflict of interest statement

Declaration of Competing Interest We know of no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome. As Corresponding Author, I confirm that the manuscript has been read and approved for submission by all the named authors.

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