Elucidation of the Role of SMAD4 in Epithelial-Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of DPC4 Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?
- PMID: 36765537
- PMCID: PMC9913373
- DOI: 10.3390/cancers15030581
Elucidation of the Role of SMAD4 in Epithelial-Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of DPC4 Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer-related mortality worldwide, with a 5-year-survival rate below 10% that is the lowest of all cancer types [...].
Conflict of interest statement
The authors declare no conflict of interest.
References
-
- Thakur A.K., Nigri J., Lac S., Leca J., Bressy C., Berthezene P., Bartholin L., Chan P., Calvo E., Iovanna J.L., et al. TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma. Cell Death Differ. 2016;23:1358–1370. doi: 10.1038/cdd.2016.18. - DOI - PMC - PubMed
-
- Na Y.R., Seok S.H., Kim D.J., Han J.H., Kim T.H., Jung H., Lee B.H., Park J.H. Bone morphogenetic protein 7 induces mesenchymal-to-epithelial transition in melanoma cells, leading to inhibition of metastasis. Cancer Sci. 2009;100:2218–2225. doi: 10.1111/j.1349-7006.2009.01301.x. - DOI - PMC - PubMed
-
- Yang J., Antin P., Berx G., Blanpain C., Brabletz T., Bronner M., Campbell K., Cano A., Casanova J., Christofori G., et al. Guidelines and definitions for research on epithelial–mesenchymal transition. Nat. Rev. Mol. Cell Biol. 2020;21:341–352. doi: 10.1038/s41580-020-0237-9. Correction in Nat. Rev. Mol. Cell Biol. 2021, 22, 834. - DOI - PMC - PubMed
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