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. 2023 Jan 19;13(3):369.
doi: 10.3390/diagnostics13030369.

Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis-A Single Center Comparative Analysis

Gina Gheorghe  1   2 , Vlad Alexandru Ionescu  1   2 , Horatiu Moldovan  1   3   4 , Camelia Cristina Diaconu  1   4   5
Affiliations

Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis-A Single Center Comparative Analysis

Gina Gheorghe et al. Diagnostics (Basel). .

Abstract

Introduction: In some patients with chronic pancreatitis, the diagnosis of pancreatic cancer can be missed. The objective of the study was to identify clinical and paraclinical data with statistical significance in the differential diagnosis between chronic pancreatitis and pancreatic cancer.

Materials and methods: We conducted a retrospective, observational study on a cohort of 120 patients hospitalized over 3 years. The patients were equally distributed in two groups: group A, with 60 patients with pancreatic cancer, and group B, with 60 patients with chronic pancreatitis. The statistical analysis was carried out by using the R program.

Results: The comparative analysis of pancreatic cancer vs. chronic pancreatitis revealed a stronger link between pancreatic cancer, female gender (p = 0.001) and age over 60 years (p < 0.001). Patients with pancreatic cancer had higher serum values of aspartate aminotransferase (p 0.005), alanine aminotransferase (p 0.006), total bilirubin (p < 0.001), direct bilirubin (p < 0.001), alkaline phosphatase (p 0.030), C-reactive protein (p = 0.049) and uric acid (p 0.001), while patients with chronic pancreatitis presented slightly higher values of amylase (p 0.020) and lipase (p 0.029).

Conclusions: Female gender, advanced age, elevated aminotransferases, cholestasis markers and uric acid were associated with a higher probability of pancreatic cancer.

Keywords: chronic pancreatitis; late diagnosis; pancreatic cancer; risk factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The risk factors for pancreatic cancer.
Figure 2
Figure 2
Predictive effect of gender on odds of pancreatic cancer vs. chronic pancreatitis.
Figure 3
Figure 3
ROC analysis of pancreatic cancer vs. age.
Figure 4
Figure 4
The influence of age on the risk of pancreatic cancer.
Figure 5
Figure 5
The influence of smoking on the risk of pancreatic cancer vs. chronic pancreatitis.
Figure 6
Figure 6
The influence of alcohol consumption on the risk of pancreatic cancer vs. chronic pancreatitis.
Figure 7
Figure 7
Median AST and ALT values in patients with pancreatic cancer (group A) vs. chronic pancreatitis (group B).
Figure 8
Figure 8
Median values of serum lipase and serum amylase in patients with pancreatic cancer vs. chronic pancreatitis.
Figure 9
Figure 9
Median serum uric acid value in patients with pancreatic cancer (group A) vs. patients with chronic pancreatitis (group B).
See this image and copyright information in PMC

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