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. 2023 Jan 20;11(3):314.
doi: 10.3390/healthcare11030314.

Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study

Shingo Nakai  1   2 , Fumihiko Suzuki  1   3 , Shigefumi Okamoto  4   5 , Sakae Miyagi  6 , Hiromasa Tsujiguchi  1   2   7 , Akinori Hara  1   2   7 , Thao Thi Thu Nguyen  8 , Yukari Shimizu  9 , Koichiro Hayashi  1   2 , Keita Suzuki  1 , Tomoko Kasahara  1   2 , Masaharu Nakamura  1 , Chie Takazawa  1 , Takayuki Kannon  7   10 , Atsushi Tajima  7   10 , Hirohito Tsuboi  11 , Noriyoshi Ogino  12   13 , Tadashi Konoshita  14 , Toshinari Takamura  15 , Hiroyuki Nakamura  1   2   7
Affiliations

Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study

Shingo Nakai et al. Healthcare (Basel). .

Abstract

The association between oral frailty (OFr) and body action has been investigated, but its association with systemic function remains unclear. Therefore, this cross-sectional study examined the association between OFr with decreased bone mineral density (BMD) and renal function in residents of Shika town, Ishikawa Prefecture, Japan aged ≥40 years. This study included 400 inhabitants. The OFr total score was assessed using three oral domains in the Kihon Checklist (a self-reported comprehensive health checklist), the number of teeth, and brushing frequency per day. Measurements were the estimated glomerular filtration rate (eGFR) and the osteo-sono assessment index (OSI). Using a two-way analysis of covariance (p = 0.002), significantly lower OSI was indicated in the eGFR < 60 and OFr group than in the eGFR of < 60 and non-OFr group after adjusting for age, body mass index, and drinking and smoking status as confounding factors. Multiple logistic regression analysis confirmed this relationship (p = 0.006). Therefore, lower BMD seems to be associated with lower renal function only when accompanied by OFr. Further longitudinal studies are needed to confirm these results.

Keywords: estimated glomerular filtration rate; logistic models; oral frailty; osteo-sono assessment index.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Participant’s selection criteria. * This range was defined from the mean ± 2 SD. Abbreviations: eGFR, estimated glomerular filtration rate; KCL, the Kihon checklist, OSI, the osteo-sono assessment index.
Figure 2
Figure 2
Post hoc Bonferroni analysis. Adjusted for age = 60.56, BMI = 23.33, drinking status = 1.52, and smoking status = 1.16. Error bar: 95% CI. Abbreviations: BMI, body mass index; CI, confidence interval; eGFR, estimated glomerular filtration rate; EMM, estimated marginal means; OFr, oral frailty; OSI, osteo-sono assessment index.
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Comment in

  • Oral frailty and associated diseases.
    Takefuji Y. Takefuji Y. Br Dent J. 2023 Sep;235(5):296. doi: 10.1038/s41415-023-6287-6. Epub 2023 Sep 8. Br Dent J. 2023. PMID: 37684441 No abstract available.

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