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. 2023 Jan 31;20(3):2579.
doi: 10.3390/ijerph20032579.

Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome

Ignacio Roy  1 , Eva Jover  1 , Lara Matilla  1 , Virginia Alvarez  1 , Amaya Fernández-Celis  1 , Maite Beunza  1 , Elena Escribano  1 , Alicia Gainza  1 , Rafael Sádaba  1 , Natalia López-Andrés  1
Affiliations

Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome

Ignacio Roy et al. Int J Environ Res Public Health. .

Abstract

Background: Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is an attractive and druggable molecule that sits at the interface between inflammation, oxidative stress and fibrosis. This study aims to analyze the relationship among sST2, oxidative stress, inflammation and echocardiographic parameters in MS patients.

Methods: Fifty-eight patients with MS were recruited and underwent physical, laboratory and transthoracic echocardiography examinations. Commercial ELISA and appropriate colorimetric assays were used to quantify serum levels of oxidative stress and inflammation markers and sST2.

Results: Circulating sST2 was increased in MS patients and was significantly correlated with the oxidative stress markers nitrotyrosine and 8-hydroxy-2'-deoxyguanosine as well as with peroxide levels. The inflammatory parameters interleukin-6, intercellular adhesion molecule-1 and myeloperoxidase were positively correlated with sST2. Noteworthy, sST2 was positively correlated with left ventricular mass, filling pressures and pulmonary arterial pressures.

Conclusion: Circulating levels of sST2 are associated with oxidative stress and inflammation burden and may underlie the pathological remodeling and dysfunction of the heart in MS patients. Our results suggest that sST2 elevation precedes diastolic dysfunction, emerging as an attractive biotarget in MS.

Keywords: inflammation; metabolic syndrome; oxidative stress; soluble ST2.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
sST2 correlates with oxidative stress markers. Serum levels of sST2 positively correlated with serum nitrotyrosine (A), 8-OHdG (B) and hydrogen peroxide (C). 8-OHdG, 8-hydroxy-2′-deoxyguanosine.
Figure 2
Figure 2
sST2 correlates with inflammatory markers. Serum levels of sST2 positively correlated with serum IL-6 (A), osteopontin (B), ICAM-1 (C) and myeloperoxidase (D). IL, interleukin; ICAM, intercellular adhesion molecule.
Figure 3
Figure 3
sST2 correlated with echocardiographic parameters. Serum levels of sST2 positively correlated with LVM (A), A-wave velocity (B), basal RV diameter (C), RV longitudinal diameter (D), RVEDA (E), RVESA (F) and RVSP (G). LVM, left ventricular mass; RV, right ventricular; RVEDA, right ventricular end-diastolic area; RVESA, right ventricular end-systolic area; RVSP, right ventricular systolic pressure.
See this image and copyright information in PMC

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