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Review
. 2023 Jan 30;24(3):2622.
doi: 10.3390/ijms24032622.

Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates

Emily A Schiller  1 , Koral Cohen  1 , Xinhua Lin  1 , Rania El-Khawam  2 , Nazeeh Hanna  1   2
Affiliations
Review

Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates

Emily A Schiller et al. Int J Mol Sci. .

Abstract

Neonates born prematurely (<37 weeks of gestation) are at a significantly increased risk of developing inflammatory conditions associated with high mortality rates, including necrotizing enterocolitis, bronchopulmonary dysplasia, and hypoxic-ischemic brain damage. Recently, research has focused on characterizing the content of extracellular vesicles (EVs), particularly microRNAs (miRNAs), for diagnostic use. Here, we describe the most recent work on EVs-miRNAs biomarkers discovery for conditions that commonly affect premature neonates.

Keywords: biomarkers; bronchopulmonary dysplasia; extracellular vesicles; hypoxic-ischemic brain damage; miRNA; necrotizing enterocolitis; neonate; prematurity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Candidate extracellular vesicles (EVs) and their miRNAs content as diagnostic biomarkers for neonatal conditions and future directions that address challenges in translation to clinical practice. EVs (extracellular vesicles); miRNA (micro-RNA); HIBD (hypoxic-ischemic brain damage); BPD (bronchopulmonary dysplasia); NEC (necrotizing enterocolitis). Created in BioRender.com.
See this image and copyright information in PMC

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